Netarsudil

What is Netarsudil?

• Netarsudil (RHOPRESSA) (netarsudil ophthalmic solution) 0.02% is a Rho kinase inhibitor used for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

What are the uses of this medicine?

• This medicine is used for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

How does this medicine work?

• Netarsudil - an amino-isoquinoline amide and inhibitor of rho kinase (rock) and norepinephrine transporter (net), with potential intraocular pressure (iop)-lowering activity.
• Upon ocular administration, netarsudil inhibits rock and the rho pathway, increases aqueous humor (ah) outflow via the trabecular pathway, and lowers iop.
• In addition, netarsudil may lower iop by decreasing episcleral venous pressure and decreasing the production of aqueous humor through inhibition of net.

Who Should Not Use this medicine ?

• This medcine have no usage limitations.

What drug interactions can this medicine cause?

• No clinically important drug interactions have been observed with RHOPRESSA.

Is this medicine FDA approved?

• It was approved for use in the United States in 2017.

How should this medicine be used?

Recommended Dosageː The recommended dosage is one drop in the affected eye(s) once daily in the evening.

Administration

• Take RHOPRESSA exactly as your doctor tells you to take it.
• Take RHOPRESSA one drop in the affected eye(s) once daily in the evening.
• If one dose is missed, treatment should continue with the next dose in the evening.
• Twice a day dosing is not well tolerated and is not recommended.
• If RHOPRESSA is to be used concomitantly with other topical ophthalmic drug products to lower IOP, administer each drug product at least 5 minutes apart.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

• As Ophthalmic solution containing 0.2 mg/mL of netarsudil.

This medicine is available in fallowing brand namesː

• RHOPRESSA

What side effects can this medication cause?

The most common side effects of this medicine include:

• conjunctival hyperemia
• corneal verticillata
• instillation site pain
• conjunctival hemorrhage

What special precautions should I follow?

• Contact lenses should be removed prior to instillation of RHOPRESSA and may be reinserted 15 minutes following its administration.
• Advise patients that if more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes between applications.
• Instruct patients to avoid allowing the tip of the dispensing container to contact the eye, surrounding structures, fingers, or any other surface in order to minimize contamination of the solution.

What to do in case of emergency/overdose?

• In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.

• Overdose related information is also available online at poisonhelp.org/help.
• In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.

Can this medicine be used in pregnancy?

• There are no available data on RHOPRESSA use in pregnant women.

Can this medicine be used in children?

• Safety and effectiveness in pediatric patients below the age of 18 years have not been established.

What are the active and inactive ingredients in this medicine?

Active ingredient:

• NETARSUDIL MESYLATE

Inactive ingredients:

• BENZALKONIUM CHLORIDE
• MANNITOL
• BORIC ACID
• SODIUM HYDROXIDE
• WATER

Who manufactures and distributes this medicine?

• Packager: Aerie Pharmaceuticals, Inc.

What should I know about storage and disposal of this medication?

• Store at 2°C to 8°C (36°F to 46°F) until opened. After opening, the product may be kept at 2°C to 25°C (36°F to 77°F) for up to 6 weeks.
• If after opening the product is kept refrigerated at 2°C to 8°C (36°F to 46°F), then the product can be used until the expiration date stamped on the bottle.
• During shipment, the bottle may be maintained at temperatures up to 40°C (104°F) for a period not exceeding 14 days.

• Dailymed label info on Netarsudil
• FDA Netarsudil

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