Lesopitron
Lesopitron is a selective serotonin receptor antagonist developed by Esteve. It is an anxiolytic drug of the azapirone class, similar to other azapirones like buspirone and ipsapirone.
Pharmacology
Lesopitron acts as a 5-HT1A receptor antagonist. The 5-HT1A receptor is a subtype of the 5-HT receptor that binds the neurotransmitter serotonin, and is prevalent in the cerebral cortex, hippocampus, septum, amygdala, and raphe nucleus, all of which are areas associated with anxiety and depression.
Clinical Use
Lesopitron is primarily used in the treatment of generalized anxiety disorder (GAD). It has been shown to have similar efficacy to benzodiazepines in treating GAD, but with fewer side effects such as sedation and dependency.
Side Effects
Common side effects of Lesopitron include dizziness, nausea, and headache. Less common side effects can include dry mouth, constipation, and changes in weight. As with all medications, it is important to monitor for any unusual or severe side effects and report them to a healthcare provider.
See Also
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Contributors: Prab R. Tumpati, MD
