Epimutation

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Epimutation
TermEpimutation
Short definitionepimutation (EH-pih-myoo-TAY-avoid) A change in the chemical structure of DNA that does not alter the DNA coding sequence. Epimutations occur in the body when chemical groups called methyl groups are added or removed from DNA, or when changes are made to proteins called histones that bind to DNA in chromosomes. 
TypeCancer terms
SpecialtyOncology
LanguageEnglish
SourceNCI
Comments


epimutation - (pronounced) (EH-pih-myoo-TAY-avoid) A change in the chemical structure of DNA that does not alter the DNA coding sequence. Epimutations occur in the body when chemical groups called methyl groups are added or removed from DNA, or when changes are made to proteins called histones that bind to DNA in chromosomes. These changes can occur with age and exposure to environmental factors such as diet, exercise, medications, and chemicals. They can affect a person's risk of disease and can be passed from parent to child. Also called epigenetic modification and epigenetic variant

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