Collagen, type XVIII, alpha 1
Collagen, Type XVIII, Alpha 1
Collagen, type XVIII, alpha 1 is a protein that in humans is encoded by the COL18A1 gene. This protein is a member of the collagen family, which is known for its role in providing structural support to tissues and organs.
Structure
Collagen type XVIII is a basement membrane collagen, which means it is found in the thin, sheet-like structures that separate and support cells in tissues. The alpha 1 chain of type XVIII collagen is characterized by its unique endostatin domain, which is known for its anti-angiogenic properties.
Function
The primary function of collagen type XVIII is to maintain the structural integrity of the extracellular matrix in various tissues. It plays a crucial role in angiogenesis, the process of new blood vessel formation, by inhibiting excessive growth through its endostatin domain. This makes it a significant factor in tumor suppression and cancer research.
Clinical Significance
Mutations in the COL18A1 gene can lead to Knobloch syndrome, a rare genetic disorder characterized by ocular and neurological abnormalities. Research into collagen type XVIII and its endostatin domain is ongoing, with potential implications for therapeutic applications in oncology and ophthalmology.
Research
Studies have shown that endostatin, derived from collagen type XVIII, can inhibit tumor angiogenesis and growth, making it a potential target for anti-cancer therapies. Ongoing research is focused on understanding the molecular mechanisms by which endostatin exerts its effects and developing drug delivery systems to enhance its therapeutic potential.
See Also
References
External Links
| Collagen | |
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| Overview | |
| Type | Protein |
| Function | Structural component of connective tissues |
| Location | Skin, tendons, ligaments, cartilage, bone, blood vessels |
| Types | |
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