OR10A5: Difference between revisions

OR10A5
Symbol	OR10A5
HGNC ID	8191
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	11q24
Locus supplementary data	–

Latest revision as of 20:20, 30 December 2024

OR10A5 is a gene that encodes a member of the olfactory receptor family of proteins. These receptors are responsible for the detection of odor molecules and are a part of the G protein-coupled receptor (GPCR) superfamily. The olfactory receptor proteins are located in the olfactory epithelium of the nasal cavity and play a crucial role in the sense of smell.

Function[edit]

Olfactory receptors, such as OR10A5, interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. These receptors share a 7-transmembrane domain structure, which is common to many neurotransmitter and hormone receptors. The olfactory receptor gene family is the largest in the human genome, highlighting the complexity and diversity of the sense of smell.

Gene Family[edit]

The OR10A5 gene is part of a large family of olfactory receptor genes. These genes are distributed across various chromosomes, with a significant cluster located on chromosome 11. The olfactory receptor gene family is characterized by a high degree of sequence diversity, which allows for the detection of a wide range of odorant molecules.

Pathways[edit]

Olfactory receptors, including OR10A5, are involved in the olfactory signaling pathway. This pathway is crucial for the detection and processing of odorant signals. Upon binding of an odorant molecule, the receptor undergoes a conformational change, activating an associated G protein. This activation leads to a cascade of intracellular events that result in the generation of an electrical signal, which is transmitted to the brain for odor perception.

Clinical Significance[edit]

While the primary function of OR10A5 is related to olfaction, variations in olfactory receptor genes can influence individual differences in smell perception. Research into these variations can provide insights into the genetic basis of olfactory disorders and contribute to the development of therapies for conditions affecting the sense of smell.

Research[edit]

Studies on olfactory receptors like OR10A5 are ongoing to better understand their role in the olfactory system and their potential implications in health and disease. The diversity of the olfactory receptor gene family makes it a rich area for research, with potential applications in neuroscience, genetics, and pharmacology.

References[edit]

External Links[edit]

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-'''OR10A5''' is a protein that in humans is encoded by the OR10A5 gene. The protein is a member of the olfactory receptor family, which is involved in the detection of smell.
+{{Infobox gene
+| name = OR10A5
+| symbol = OR10A5
+| HGNCid = 8191
+| chromosome = 11
+| arm = q
+| band = 24
+| locus = 11q24
+| gene_family = Olfactory receptor
+}}
-== Function ==
+'''OR10A5''' is a gene that encodes a member of the olfactory receptor family of proteins. These receptors are responsible for the detection of odor molecules and are a part of the [[G protein-coupled receptor]] (GPCR) superfamily. The olfactory receptor proteins are located in the [[olfactory epithelium]] of the nasal cavity and play a crucial role in the sense of [[smell]].
-[[Olfactory receptors]] interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.
-== Gene ==
+==Function==
-The OR10A5 gene is located on [[chromosome 1]], specifically at 1q44. The gene spans approximately 1 kilobase and consists of one exon. The OR10A5 gene is a part of a cluster of similar genes on chromosome 1. This cluster also includes OR10A4, OR10A6, and OR10A7.
+Olfactory receptors, such as OR10A5, interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. These receptors share a 7-transmembrane domain structure, which is common to many neurotransmitter and hormone receptors. The olfactory receptor gene family is the largest in the human genome, highlighting the complexity and diversity of the sense of smell.
-== Clinical significance ==
+==Gene Family==
-While the specific clinical significance of OR10A5 is not fully understood, olfactory receptors in general have been implicated in various diseases. For example, mutations in olfactory receptors have been associated with a decreased sense of smell, known as [[anosmia]]. Further research is needed to determine the specific role of OR10A5 in human health and disease.
+The OR10A5 gene is part of a large family of olfactory receptor genes. These genes are distributed across various chromosomes, with a significant cluster located on chromosome 11. The olfactory receptor gene family is characterized by a high degree of sequence diversity, which allows for the detection of a wide range of odorant molecules.
-[[File:OR10A5 gene location on human chromosome 1.png|thumb|right|300px|Location of OR10A5 gene on human chromosome 1.]]
+==Pathways==
+Olfactory receptors, including OR10A5, are involved in the olfactory signaling pathway. This pathway is crucial for the detection and processing of odorant signals. Upon binding of an odorant molecule, the receptor undergoes a conformational change, activating an associated G protein. This activation leads to a cascade of intracellular events that result in the generation of an electrical signal, which is transmitted to the brain for odor perception.
-== See also ==
+==Clinical Significance==
+While the primary function of OR10A5 is related to olfaction, variations in olfactory receptor genes can influence individual differences in smell perception. Research into these variations can provide insights into the genetic basis of olfactory disorders and contribute to the development of therapies for conditions affecting the sense of smell.
+==Research==
+Studies on olfactory receptors like OR10A5 are ongoing to better understand their role in the olfactory system and their potential implications in health and disease. The diversity of the olfactory receptor gene family makes it a rich area for research, with potential applications in [[neuroscience]], [[genetics]], and [[pharmacology]].
+==See Also==
 * [[Olfactory receptor]]
 * [[G protein-coupled receptor]]
-* [[Anosmia]]
+* [[Olfactory system]]
+==References==
+<references />
-== References ==
+==External Links==
-<references/>
+* [https://www.ncbi.nlm.nih.gov/gene/OR10A5 OR10A5 Gene - NCBI]
+* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=OR10A5 OR10A5 Gene - GeneCards]
+{{Olfactory receptors}}
-[[Category:Genes on human chromosome 1]]
 [[Category:Olfactory receptors]]
 [[Category:G protein-coupled receptors]]
+[[Category:Human genes]]
-{{G protein-coupled receptors}}
-{{Olfactory receptors}}
-{{medicine-stub}}