Butriptyline: Difference between revisions

Butriptyline
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Latest revision as of 03:44, 13 February 2025

Overview of the antidepressant drug Butriptyline

Butriptyline, also known by its trade name Evadyne, is a tricyclic antidepressant (TCA) that was developed in the 1960s. It is primarily used for the treatment of depression.

Pharmacology[edit]

Butriptyline is a member of the tricyclic antidepressant class, which works by inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine in the brain. This action increases the levels of these neurotransmitters in the synaptic cleft, thereby enhancing mood and alleviating depressive symptoms.

Mechanism of Action[edit]

Butriptyline acts primarily as a serotonin-norepinephrine reuptake inhibitor (SNRI). It also has affinity for various receptors, including histamine and muscarinic receptors, which contributes to its side effect profile.

Clinical Use[edit]

Butriptyline is indicated for the treatment of major depressive disorder. It is less commonly used today due to the availability of newer antidepressants with more favorable side effect profiles.

Side Effects[edit]

Common side effects of Butriptyline include dry mouth, constipation, urinary retention, and sedation. Due to its anticholinergic properties, it may also cause blurred vision and tachycardia.

History[edit]

Butriptyline was first introduced in the 1960s. It was marketed under the trade name Evadyne. However, its use has declined over the years as newer antidepressants, such as SSRIs and SNRIs, have become more popular due to their improved safety and tolerability.

Related pages[edit]

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-'''Butriptyline''' is a tricyclic antidepressant (TCA) that belongs to the dibenzocycloheptene class, closely related to other antidepressants such as [[amitriptyline]] and [[nortriptyline]]. It was developed in the 1960s and has been used in the treatment of depression and anxiety disorders. Butriptyline works by inhibiting the reuptake of neurotransmitters, specifically [[norepinephrine]] and [[serotonin]], in the brain, which helps to elevate mood and alleviate symptoms of depression.
+{{Short description|Overview of the antidepressant drug Butriptyline}}
+{{Drugbox
+| image = Butriptyline.svg
+| image_size = 200px
+| image_alt = Chemical structure of Butriptyline
+}}
-== Pharmacology ==
+'''Butriptyline''', also known by its trade name '''Evadyne''', is a [[tricyclic antidepressant]] (TCA) that was developed in the 1960s. It is primarily used for the treatment of [[depression (mood)|depression]].
-Butriptyline's mechanism of action involves the inhibition of the reuptake of norepinephrine and serotonin, two key neurotransmitters in the central nervous system involved in mood regulation. By preventing their reuptake, butriptyline increases the concentration of these neurotransmitters in the synaptic cleft, enhancing neurotransmission and improving mood. Additionally, butriptyline has anticholinergic properties, which contribute to its side effect profile.
-== Indications ==
+==Pharmacology==
-Butriptyline is primarily indicated for the treatment of [[Major depressive disorder|MDD]], but it may also be used off-label for the management of [[anxiety disorders]], [[neuropathic pain]], and in some cases, for the treatment of [[insomnia]] due to its sedative effects.
+Butriptyline is a member of the [[tricyclic antidepressant]] class, which works by inhibiting the reuptake of [[neurotransmitter|neurotransmitters]] such as [[serotonin]] and [[norepinephrine]] in the brain. This action increases the levels of these neurotransmitters in the synaptic cleft, thereby enhancing mood and alleviating depressive symptoms.
-== Side Effects ==
+===Mechanism of Action===
-The side effect profile of butriptyline is similar to that of other TCAs and includes drowsiness, dry mouth, blurred vision, constipation, urinary retention, and weight gain. Due to its anticholinergic effects, butriptyline is contraindicated in patients with a history of [[glaucoma]], urinary retention, and certain types of [[cardiac arrhythmia]]. It is also associated with an increased risk of [[suicidality]] in children, adolescents, and young adults.
+[[File:Butriptyline.svg|thumb|right|Chemical structure of Butriptyline]]
+Butriptyline acts primarily as a [[serotonin-norepinephrine reuptake inhibitor]] (SNRI). It also has affinity for various [[receptor (biochemistry)|receptors]], including [[histamine receptor|histamine]] and [[muscarinic acetylcholine receptor|muscarinic]] receptors, which contributes to its side effect profile.
-== Contraindications ==
+==Clinical Use==
-Butriptyline is contraindicated in individuals with hypersensitivity to the drug, recent myocardial infarction, severe liver impairment, and in those taking monoamine oxidase inhibitors (MAOIs). Caution is advised when prescribing butriptyline to elderly patients due to the increased risk of falls and fractures.
+Butriptyline is indicated for the treatment of major depressive disorder. It is less commonly used today due to the availability of newer antidepressants with more favorable side effect profiles.
-== Drug Interactions ==
+===Side Effects===
-Butriptyline can interact with a wide range of medications, including other antidepressants, anticholinergic agents, sympathomimetic drugs, and antihypertensive medications. It is important to review a patient's medication history to avoid potentially harmful drug interactions.
+Common side effects of Butriptyline include [[dry mouth]], [[constipation]], [[urinary retention]], and [[sedation]]. Due to its anticholinergic properties, it may also cause [[blurred vision]] and [[tachycardia]].
-== Dosage and Administration ==
+==History==
-The dosage of butriptyline varies depending on the condition being treated and the patient's response to therapy. Treatment typically starts with a low dose, which is gradually increased until the desired therapeutic effect is achieved. It is important to monitor patients closely for signs of improvement and any adverse effects.
+Butriptyline was first introduced in the 1960s. It was marketed under the trade name Evadyne. However, its use has declined over the years as newer antidepressants, such as [[selective serotonin reuptake inhibitor|SSRIs]] and [[serotonin-norepinephrine reuptake inhibitor|SNRIs]], have become more popular due to their improved safety and tolerability.
-== Conclusion ==
+==Related pages==
-Butriptyline is a valuable medication in the treatment of depression and other mood disorders. However, its use must be carefully considered due to its side effect profile and potential for drug interactions. Patients should be closely monitored for therapeutic efficacy and adverse effects, and adjustments to the treatment regimen should be made as necessary.
+* [[Tricyclic antidepressant]]
+* [[Serotonin-norepinephrine reuptake inhibitor]]
+* [[Depression (mood)]]
+[[Category:Tricyclic antidepressants]]
 [[Category:Antidepressants]]
-[[Category:Tricyclic antidepressants]]
-{{medicine-stub}}
-{{No image}}