Renal cell carcinoma: Difference between revisions
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'''Renal cell carcinoma''' ('''RCC''') is a type of [[kidney cancer]] that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine. | {{SI}} | ||
{{Infobox medical condition | |||
| name = Renal cell carcinoma | |||
| image = [[File:Clear_cell_renal_cell_carcinoma_high_mag.jpg|left|thumb|alt=Clear cell renal cell carcinoma high magnification|upright=1.2]] | |||
| caption = Micrograph of clear cell renal cell carcinoma, the most common type of renal cell carcinoma | |||
| field = [[Oncology]] | |||
| synonyms = Hypernephroma, renal adenocarcinoma, kidney cancer | |||
| symptoms = [[Hematuria]], [[flank pain]], [[abdominal mass]], [[weight loss]], [[fever]] | |||
| complications = [[Metastasis]], [[paraneoplastic syndrome]] | |||
| onset = Typically between ages 60 and 70 | |||
| duration = Long-term | |||
| types = [[Clear cell renal cell carcinoma]], [[papillary renal cell carcinoma]], [[chromophobe renal cell carcinoma]] | |||
| causes = [[Smoking]], [[obesity]], [[hypertension]], [[genetic factors]] | |||
| risks = [[Von Hippel-Lindau disease]], [[tuberous sclerosis]], [[family history]] | |||
| diagnosis = [[CT scan]], [[MRI]], [[ultrasound]], [[biopsy]] | |||
| differential = [[Transitional cell carcinoma]], [[renal oncocytoma]], [[angiomyolipoma]] | |||
| prevention = [[Smoking cessation]], [[weight management]], [[blood pressure control]] | |||
| treatment = [[Surgery]], [[targeted therapy]], [[immunotherapy]], [[radiation therapy]] | |||
| medication = [[Sunitinib]], [[pazopanib]], [[nivolumab]], [[ipilimumab]] | |||
| prognosis = Variable, depends on stage and grade | |||
| frequency = Approximately 2-3% of adult cancers | |||
| deaths = Approximately 140,000 worldwide annually | |||
}} | |||
[[File:Renal clear cell ca (1) Nephrectomy.jpg|left|thumb|Renal clear cell carcinoma nephrectomy]] | |||
[[File:Papillary renal cell carcinoma 1.jpg|left|thumb|Papillary renal cell carcinoma]] | |||
[[File:Histopathology of chromophobe renal cell carcinoma.png|thumb|Histopathology of chromophobe renal cell carcinoma]] | |||
[[File:Renal cell carcinoma.jpg|thumb|Renal cell carcinoma]] | |||
[[File:Renal tumors by relative incidence and prognosis.png|thumb|Renal tumors by relative incidence and prognosis]] | |||
[[File:Kidney cancer.jpg|left|thumb|Kidney cancer]] | |||
[[File:Embolization kidney.jpg|left|thumb|Embolization kidney]] | |||
'''Renal cell carcinoma''' ('''RCC''') is a type of [[kidney cancer]] that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine. | |||
== Signs and Symptoms == | == Signs and Symptoms == | ||
The classic triad of [[hematuria]], pain, and an abdominal mass is only present in 10% of cases, and is generally indicative of more advanced disease. Today, most cases of RCC are asymptomatic and are detected incidentally on imaging for other reasons. | The classic triad of [[hematuria]], pain, and an abdominal mass is only present in 10% of cases, and is generally indicative of more advanced disease. Today, most cases of RCC are asymptomatic and are detected incidentally on imaging for other reasons. | ||
== Causes == | == Causes == | ||
RCC is associated with several hereditary conditions, including [[Von Hippel-Lindau disease]], hereditary leiomyomatosis and RCC, Birt-Hogg-Dubé syndrome, and hereditary papillary renal carcinoma. | RCC is associated with several hereditary conditions, including [[Von Hippel-Lindau disease]], hereditary leiomyomatosis and RCC, Birt-Hogg-Dubé syndrome, and hereditary papillary renal carcinoma. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of RCC involves a combination of [[medical imaging]] (such as CT scanning or ultrasound), blood and urine tests, and often, a biopsy. | Diagnosis of RCC involves a combination of [[medical imaging]] (such as CT scanning or ultrasound), blood and urine tests, and often, a biopsy. | ||
== Treatment == | == Treatment == | ||
Treatment options for RCC include [[surgery]], [[radiation therapy]], [[immunotherapy]], [[targeted therapy]], and in some cases, [[chemotherapy]]. | Treatment options for RCC include [[surgery]], [[radiation therapy]], [[immunotherapy]], [[targeted therapy]], and in some cases, [[chemotherapy]]. | ||
== Prognosis == | == Prognosis == | ||
The prognosis for RCC varies widely depending on the stage at which the cancer is diagnosed. | The prognosis for RCC varies widely depending on the stage at which the cancer is diagnosed. | ||
== See Also == | == See Also == | ||
* [[Kidney cancer]] | * [[Kidney cancer]] | ||
* [[Von Hippel-Lindau disease]] | * [[Von Hippel-Lindau disease]] | ||
* [[Birt-Hogg-Dubé syndrome]] | * [[Birt-Hogg-Dubé syndrome]] | ||
== References == | == References == | ||
<references /> | <references /> | ||
[[Category:Kidney diseases]] | [[Category:Kidney diseases]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Urology]] | [[Category:Urology]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 12:12, 14 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Renal cell carcinoma | |
|---|---|
 | |
| Synonyms | Hypernephroma, renal adenocarcinoma, kidney cancer |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Hematuria, flank pain, abdominal mass, weight loss, fever |
| Complications | Metastasis, paraneoplastic syndrome |
| Onset | Typically between ages 60 and 70 |
| Duration | Long-term |
| Types | Clear cell renal cell carcinoma, papillary renal cell carcinoma, chromophobe renal cell carcinoma |
| Causes | Smoking, obesity, hypertension, genetic factors |
| Risks | Von Hippel-Lindau disease, tuberous sclerosis, family history |
| Diagnosis | CT scan, MRI, ultrasound, biopsy |
| Differential diagnosis | Transitional cell carcinoma, renal oncocytoma, angiomyolipoma |
| Prevention | Smoking cessation, weight management, blood pressure control |
| Treatment | Surgery, targeted therapy, immunotherapy, radiation therapy |
| Medication | Sunitinib, pazopanib, nivolumab, ipilimumab |
| Prognosis | Variable, depends on stage and grade |
| Frequency | Approximately 2-3% of adult cancers |
| Deaths | Approximately 140,000 worldwide annually |
_Nephrectomy.jpg){kind=spacer}
Renal cell carcinoma (RCC) is a type of kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine.
Signs and Symptoms[edit]
The classic triad of hematuria, pain, and an abdominal mass is only present in 10% of cases, and is generally indicative of more advanced disease. Today, most cases of RCC are asymptomatic and are detected incidentally on imaging for other reasons.
Causes[edit]
RCC is associated with several hereditary conditions, including Von Hippel-Lindau disease, hereditary leiomyomatosis and RCC, Birt-Hogg-Dubé syndrome, and hereditary papillary renal carcinoma.
Diagnosis[edit]
Diagnosis of RCC involves a combination of medical imaging (such as CT scanning or ultrasound), blood and urine tests, and often, a biopsy.
Treatment[edit]
Treatment options for RCC include surgery, radiation therapy, immunotherapy, targeted therapy, and in some cases, chemotherapy.
Prognosis[edit]
The prognosis for RCC varies widely depending on the stage at which the cancer is diagnosed.
See Also[edit]
References[edit]
<references />
