Troparil: Difference between revisions

Latest revision as of 02:50, 11 December 2024

An overview of Troparil, its uses, and related information

Troparil is a synthetic stimulant drug of the phenyltropane class. It is primarily known for its potential use in scientific research and its effects on the central nervous system. Troparil is structurally related to cocaine and acts as a dopamine reuptake inhibitor, which leads to increased levels of dopamine in the brain.

Pharmacology[edit]

Troparil functions by inhibiting the dopamine transporter (DAT), which prevents the reuptake of dopamine into presynaptic neurons. This action results in elevated extracellular concentrations of dopamine, leading to enhanced dopaminergic neurotransmission. The increased dopamine levels are associated with the stimulant effects of Troparil, which include increased alertness, euphoria, and enhanced cognitive function.

Potential Uses[edit]

Troparil has been studied for its potential applications in various fields:

Research Tool: Due to its ability to selectively inhibit dopamine reuptake, Troparil is used in scientific research to study the dopaminergic system and its role in various neurological and psychiatric disorders.

Medical Imaging: Troparil has been investigated as a radioligand in positron emission tomography (PET) imaging to study the distribution and density of dopamine transporters in the brain.

Safety and Legal Status[edit]

Troparil is not approved for medical use in humans and is primarily used in research settings. Its legal status varies by country, and it is often classified as a controlled substance due to its structural similarity to cocaine and potential for abuse.

History[edit]

Troparil was first synthesized in the 1970s as part of efforts to develop non-addictive analogs of cocaine. Researchers aimed to create compounds that retained the stimulant effects of cocaine without its addictive properties. Although Troparil has not been developed into a therapeutic drug, it remains of interest in scientific research.

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-[[Image:Troparil.png|thumb|right|Chemical structure of Troparil]]
+{{Short description|An overview of Troparil, its uses, and related information}}
-'''Troparil''' is a chemical compound that belongs to the class of tropane-based drugs. It is primarily known for its potential use as a stimulant and a psychostimulant medication. Troparil is chemically related to cocaine and has been the subject of research due to its psychoactive properties.
-== Chemical Structure ==
+[[File:Phenyltropane 11a - WIN 35065-2 - Troparil.svg|thumb|Chemical structure of Troparil]]
-Troparil has the following chemical structure:
-== Pharmacology ==
+'''Troparil''' is a synthetic stimulant drug of the phenyltropane class. It is primarily known for its potential use in scientific research and its effects on the central nervous system. Troparil is structurally related to [[cocaine]] and acts as a dopamine reuptake inhibitor, which leads to increased levels of dopamine in the brain.
-Troparil acts as a dopamine reuptake inhibitor, similar to cocaine. It inhibits the reuptake of dopamine in the brain, leading to increased dopamine levels in the synaptic cleft. This increase in dopamine is associated with the rewarding and stimulating effects of the drug.
-== Research and Uses ==
+==Pharmacology==
-Troparil has been studied in the context of research into psychostimulant medications and their potential therapeutic applications. However, it is important to note that Troparil is not approved for medical use in most countries due to its potential for abuse and addiction.
+Troparil functions by inhibiting the dopamine transporter (DAT), which prevents the reuptake of dopamine into presynaptic neurons. This action results in elevated extracellular concentrations of dopamine, leading to enhanced dopaminergic neurotransmission. The increased dopamine levels are associated with the stimulant effects of Troparil, which include increased alertness, euphoria, and enhanced cognitive function.
-== Legal Status ==
+==Potential Uses==
-The legal status of Troparil varies from country to country. In many places, it is classified as a controlled substance due to its similarity to cocaine and potential for misuse.
+Troparil has been studied for its potential applications in various fields:
-== Risks and Side Effects ==
+* '''Research Tool''': Due to its ability to selectively inhibit dopamine reuptake, Troparil is used in scientific research to study the dopaminergic system and its role in various neurological and psychiatric disorders.
-The use of Troparil is associated with several risks and potential side effects, including:
-* Addiction and dependence
+* '''Medical Imaging''': Troparil has been investigated as a radioligand in positron emission tomography (PET) imaging to study the distribution and density of dopamine transporters in the brain.
-* Cardiovascular effects, such as increased heart rate and blood pressure
-* Anxiety and agitation
+==Safety and Legal Status==
-* Insomnia
+Troparil is not approved for medical use in humans and is primarily used in research settings. Its legal status varies by country, and it is often classified as a controlled substance due to its structural similarity to cocaine and potential for abuse.
-* Psychiatric disturbances
+==History==
+Troparil was first synthesized in the 1970s as part of efforts to develop non-addictive analogs of cocaine. Researchers aimed to create compounds that retained the stimulant effects of cocaine without its addictive properties. Although Troparil has not been developed into a therapeutic drug, it remains of interest in scientific research.
+==See Also==
+* [[Cocaine]]
+* [[Dopamine reuptake inhibitor]]
+* [[Phenyltropane]]
+* [[Stimulant]]
+{{Drug class}}
+{{Psychoactive drugs}}
-== Summary ==
-Troparil is a stimulant drug used in scientific research. Troparil is a phenyltropane-based dopamine reuptake inhibitor (DRI) that is derived from methylecgonidine. Troparil is a few times more potent than cocaine as a dopamine reuptake inhibitor, but is less potent as a serotonin reuptake inhibitor, and has a duration spanning a few times longer, since the phenyl ring is directly connected to the tropane ring through a non-hydrolyzable carbon-carbon bond. The lack of an ester linkage removes the local anesthetic action from the drug, so troparil is a pure stimulant. This change in activity also makes troparil slightly less cardiotoxic than cocaine. The most commonly used form of troparil is the tartrate salt.
-{{stub}}
-[[Category:Pharmaceuticals]]
 [[Category:Stimulants]]
-[[Category:Psychoactive substances]]
+[[Category:Phenyltropanes]]
+[[Category:Dopamine reuptake inhibitors]]