Template:Sympatholytic antihypertensives

From WikiMD's Wellness Encyclopedia

(Redirected from Template:Endothelial antihypertensives)

Sympatholytic (and closely related) antihypertensives (C02)

Sympatholytics
(antagonize α-adrenergic
vasoconstriction)

Central

α₂-Adrenergic receptor agonists	* Clonidine Guanabenz Guanfacine Guanoxabenz Methyldopa^# Tiamenidine^‡
Adrenergic release inhibitors	* Bethanidine Bretylium Debrisoquine Guanadrel Guanazodine Guancydine Guanethidine Guanoclor Guanoxan
Imidazoline receptor agonists	* Moxonidine Rilmenidine Tolonidine
Ganglion-blocking/nicotinic antagonists	* Hexamethonium^‡ Mecamylamine Pentolinium Trimethaphan

Peripheral

Indirect

Monoamine oxidase inhibitors	* Pargyline^‡
VMAT inhibitors	* Bietaserpine Deserpidine Methoserpidine Reserpine Syrosingopine
Tyrosine hydroxylase inhibitors	* Metirosine

Direct

α₁-Adrenergic receptor blockers	* Doxazosin Ketanserin Indoramin Prazosin Trimazosin Urapidil
Non-selective α-adrenergic receptor blockers	* Phentolamine

Other antagonists

Serotonin receptor antagonists	* Ketanserin Lidanserin
Endothelin receptor antagonists (for PH )	* dual (Aprocitentan, Bosentan, Macitentan (+tadalafil), Riociguat) selective (Ambrisentan (+tadalafil), Sitaxentan, Sotatercept)

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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