Debrisoquine
Debrisoquine
Debrisoquine (/dɛˈbrɪsoʊkwiːn/) is a pharmacological agent used primarily as a research tool in the study of drug metabolism.
Etymology
The term "Debrisoquine" is derived from the chemical name 4,5-dihydro-1H-imidazol-2-amine and the brand name Debrisan, under which it was originally marketed.
Usage
Debrisoquine is used as a probe drug to assess the activity of the cytochrome P450 enzyme CYP2D6, which is involved in the metabolism of many commonly used drugs. It is not used therapeutically, but its metabolite, 4-hydroxydebrisoquine, is measured in urine to determine an individual's CYP2D6 activity.
Related Terms
- Pharmacogenetics: The study of how genes affect a person's response to drugs. This relatively new field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications and doses that will be tailored to a person's genetic makeup.
- Cytochrome P450: A group of enzymes that are involved in drug metabolism. CYP2D6, one of the enzymes in this group, is responsible for the metabolism of debrisoquine.
- Metabolite: A substance formed in or necessary for metabolism. In the case of debrisoquine, its metabolite 4-hydroxydebrisoquine is measured to determine CYP2D6 activity.
External links
- Medical encyclopedia article on Debrisoquine
- Wikipedia's article - Debrisoquine
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