Signet ring cell carcinoma

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD's weight loss doctor NYC
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Signet ring cell carcinoma
Synonyms	Signet ring cell cancer
Pronounce	N/A
Specialty	N/A
Symptoms	Weight loss, abdominal pain, nausea, vomiting
Complications	Metastasis, obstruction
Onset	Typically in adulthood
Duration	Chronic
Types	Gastric cancer, colorectal cancer, breast cancer
Causes	Genetic mutations, environmental factors
Risks	Family history, smoking, dietary factors
Diagnosis	Biopsy, endoscopy, imaging studies
Differential diagnosis	Adenocarcinoma, lymphoma, gastrointestinal stromal tumor
Prevention	Healthy diet, regular screening
Treatment	Surgery, chemotherapy, radiation therapy
Medication	N/A
Prognosis	Variable, often poor
Frequency	Rare
Deaths	N/A

Signet ring cell carcinoma - very high magnification

Gastric signet ring cell carcinoma histopathology

Histopathology of signet ring cell carcinoma of ileum

Signet ring cell carcinoma (SRCC) is a rare form of cancer that primarily affects the stomach or gastric region, but can also occur in other parts of the body such as the breast, colon, prostate, bladder, pancreas, and lung. It is named for the resemblance of the cancer cells to signet rings when viewed under a microscope.

Introduction

SRCC is characterized by cells that are filled with mucin, a type of protein. This causes the nucleus of the cell to be pushed to the periphery, giving it the appearance of a signet ring. The presence of these cells is a defining characteristic of this type of cancer.

Symptoms

The symptoms of SRCC can vary depending on the location of the cancer. In the case of gastric SRCC, symptoms may include abdominal pain, nausea, vomiting, and weight loss. If the cancer is located in the colon, symptoms may include constipation, diarrhea, and rectal bleeding.

Diagnosis

Diagnosis of SRCC typically involves a combination of physical examination, medical history, and imaging tests. A biopsy may also be performed to confirm the diagnosis. The biopsy sample is examined under a microscope to look for the presence of signet ring cells.

Treatment

Treatment for SRCC depends on the stage of the cancer and the overall health of the patient. Options may include surgery, chemotherapy, and radiation therapy. In some cases, a combination of these treatments may be used.

Prognosis

The prognosis for SRCC is generally poor, as this type of cancer is often diagnosed at a late stage. However, early detection and treatment can improve the prognosis.

See also

• Cancer
• Stomach cancer
• Colon cancer
• Breast cancer
• Prostate cancer
• Bladder cancer
• Pancreatic cancer
• Lung cancer