Caudal regression syndrome

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Caudal Regression Syndrome

Caudal Regression Syndrome (CRS), also known as Sacral Agenesis (pronounced: kaw-dal reh-gresh-un sin-drohm), is a rare congenital disorder that affects the development of the lower (caudal) half of the body. The term "caudal" is derived from the Latin word "cauda", meaning tail, and "regression" refers to the underdevelopment or absence of normal structures.

Definition

Caudal Regression Syndrome is characterized by abnormal development of the lower spine (the caudal vertebrae), and in severe cases, can involve the spinal cord, kidneys, and lower limbs. The severity of the condition can vary widely, from minor anomalies to significant physical disability.

Symptoms

Symptoms of Caudal Regression Syndrome can include limb abnormalities, neurological impairment, and issues with the gastrointestinal system, genitourinary system, and cardiovascular system. The specific symptoms and their severity can vary greatly from one person to another.

Causes

The exact cause of Caudal Regression Syndrome is unknown, but it is believed to be multifactorial, involving both genetic and environmental factors. It is often associated with maternal diabetes, especially when poorly controlled during the early stages of pregnancy.

Diagnosis

Diagnosis of Caudal Regression Syndrome is typically made based on physical examination, medical history, and imaging studies such as ultrasound, MRI, or X-ray of the spine.

Treatment

Treatment for Caudal Regression Syndrome is symptomatic and supportive, and may include physical therapy, surgical interventions, and management of associated conditions.

Prognosis

The prognosis for individuals with Caudal Regression Syndrome varies widely depending on the severity of the condition and the presence of associated anomalies.

See Also

External links

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