Probenecid and colchicine

Probenecid and Colchicine

Probenecid and colchicine (pronunciation: pro-BEN-e-sid and KOL-chi-seen) is a combination medication used primarily to treat gout and gouty arthritis.

Etymology

The term probenecid is derived from the chemical name p-ropylbenzene-acid. The term colchicine is derived from the plant that produces it, the autumn crocus, Colchicum autumnale.

Pharmacology

Probenecid works by increasing the kidneys' excretion of uric acid, thereby reducing the concentration of uric acid in the body. Colchicine works by decreasing swelling and lessening the build-up of uric acid crystals that cause pain in the affected joint(s).

Usage

This medication is used to prevent or treat gout attacks (sudden, severe pain in one or more joints caused by abnormally high levels of a substance called uric acid in the blood) in adults, and to treat gout attacks in children aged 2 years and older.

Related Terms

• Uric Acid
• Gout
• Gouty Arthritis
• Kidneys
• Pharmacology
• Medication

See Also

• Nonsteroidal anti-inflammatory drug
• Corticosteroids
• Allopurinol

External links

• Medical encyclopedia article on Probenecid and colchicine
• Wikipedia's article - Probenecid and colchicine

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