Poorly differentiated thyroid cancer
| Poorly differentiated thyroid carcinoma | |
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| Synonyms | PDTC |
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Poorly differentiated thyroid carcinoma is malignant neoplasm of follicular cell origin showing intermediate histopathological patterns between differentiated and undifferentiated thyroid cancers.[1]
Histopathology
- Presence of small cells with round nuclei and scant cytoplasm with a diffuse solid pattern
- Round or oval nests (insulae) or in trabeculae.
- Solid growth and presence of microfollicles, some of which contain dense colloid.
- Extrathyroidal extension and blood vessel invasion
- Foci of necrosis,
- Larger than 5 cm in greatest diameter at diagnosis
Epidemiology
- PDTC affects predominantly females about 55 years of age
References
- ↑ , Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach., Am J Surg Pathol, 2007, Vol. 31(Issue: 8), pp. 1256–64, DOI: 10.1097/PAS.0b013e3180309e6a, PMID: 17667551,
External links
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Contributors: Prab R. Tumpati, MD
