MT-TY

MT-TY is a gene that in humans encodes the mitochondrial tyrosine tRNA (transfer RNA). This gene is located within the mitochondrial DNA and plays a crucial role in the synthesis of proteins within the mitochondria.

Function

The MT-TY gene is responsible for the production of a type of transfer RNA that helps in the assembly of amino acids into functioning proteins. Specifically, it assists in the incorporation of the amino acid tyrosine into these proteins. This process is essential for the normal functioning of the mitochondria and, by extension, the cells and tissues of the body.

Clinical significance

Mutations in the MT-TY gene have been associated with a variety of mitochondrial disorders. These include mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), myoclonic epilepsy with ragged-red fibers (MERRF), and Leber's hereditary optic neuropathy (LHON). These conditions are characterized by a wide range of symptoms, including muscle weakness, neurological problems, and vision loss.

Research

Research into the MT-TY gene and its associated disorders is ongoing. Scientists are particularly interested in understanding how mutations in this gene lead to the diverse symptoms seen in mitochondrial disorders. This knowledge could potentially lead to new treatments for these conditions.

Mitochondrial DNA. MT-TY is one of the 22 tRNA genes (light blue).

See also

• Mitochondrial disease
• Mitochondrial DNA
• Transfer RNA

References

   This article is a medical stub. You can help WikiMD by expanding it!