Glucuronic acid

Glucuronic acid is a uronic acid that plays significant roles in the metabolism of microorganisms, plants, and animals. It is derived from glucose, a type of sugar, and is a key component in the detoxification process of harmful substances in the body.

Structure and Properties

Glucuronic acid is a carboxylic acid that consists of six carbon atoms. It is a monosaccharide sugar acid derived from glucose, with the sixth carbon atom oxidized to a carboxylic acid.

Biological Role

In humans and other animals, glucuronic acid is involved in the detoxification of substances by the liver. It is a part of the glucuronidation process, where it combines with toxic substances to make them more water-soluble, allowing for easier excretion through the urine or bile.

Medical Significance

Glucuronic acid is crucial in the metabolism of certain drugs, including nonsteroidal anti-inflammatory drugs (NSAIDs), benzodiazepines, and morphine. It is also involved in the metabolism of bilirubin, a waste product of red blood cell breakdown, and its deficiency can lead to conditions like Gilbert's syndrome.

See Also

• Glucuronidation
• Uronic acid
• Metabolism
• Detoxification

References

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  Beta D-Glucuronic acid structure

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  Glucuronic acid

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  Glucuronidation of Biphenyl Amine