Generalized bullous fixed drug eruption

Generalized Bullous Fixed Drug Eruption

Generalized Bullous Fixed Drug Eruption (GBFDE) (pronunciation: jen-er-uh-lahyzd boo-luhs fikst druhg ih-ruhp-shuhn) is a rare and severe form of fixed drug eruption, characterized by the development of widespread bullous lesions following the administration of a drug.

Etymology

The term is derived from the words 'generalized', meaning widespread; 'bullous', referring to the formation of blisters or bullae; 'fixed', indicating the recurrence of lesions at the same site upon re-exposure to the drug; and 'drug eruption', which refers to an adverse drug reaction on the skin.

Definition

Generalized Bullous Fixed Drug Eruption is a type of adverse drug reaction that manifests on the skin. It is characterized by the sudden onset of widespread bullous lesions or blisters that recur at the same site each time the causative drug is administered. The condition is typically associated with the use of certain medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, and anticonvulsants.

Symptoms

The primary symptom of GBFDE is the appearance of widespread bullous lesions or blisters on the skin. These lesions typically recur at the same site each time the causative drug is administered. Other symptoms may include itching, burning sensation, and pain at the site of the lesions.

Diagnosis

Diagnosis of GBFDE is primarily based on the clinical presentation and the patient's drug history. A skin biopsy may be performed to confirm the diagnosis. In some cases, a patch test may be used to identify the causative drug.

Treatment

Treatment of GBFDE involves discontinuation of the causative drug and management of the symptoms. Topical or systemic corticosteroids may be used to reduce inflammation and speed up the healing process. In severe cases, hospitalization may be required.

Related Terms

External links

Medical encyclopedia article on Generalized bullous fixed drug eruption
Wikipedia's article - Generalized bullous fixed drug eruption

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Generalized bullous fixed drug eruption