Drug-induced lupus erythematosus
Drug-induced lupus erythematosus (pronounced: drug-in-duced loo-pus er-i-the-ma-toe-sus) is a rare condition that is triggered by certain prescription medications. It is similar to systemic lupus erythematosus, a systemic autoimmune disease, but it is caused by an adverse reaction to certain medications.
Etymology
The term "lupus" is derived from the Latin word for wolf, due to the characteristic rash that was thought to resemble a wolf's bite. "Erythematosus" comes from the Greek word "erythros" which means red, referring to the red rash that is often present in lupus. The term "drug-induced" is self-explanatory, referring to the fact that the condition is caused by certain drugs.
Causes
Drug-induced lupus erythematosus is caused by a reaction to certain prescription medications. These can include hydralazine, procainamide, and isoniazid. In most cases, the condition develops after taking these medications for at least three months.
Symptoms
Symptoms of drug-induced lupus erythematosus can include arthralgia, myalgia, serositis, fatigue, and fever. A characteristic rash may also be present, particularly in areas of the skin that are exposed to the sun.
Diagnosis
Diagnosis of drug-induced lupus erythematosus is based on a combination of clinical symptoms and laboratory tests. The antihistone antibody test is particularly useful, as these antibodies are present in up to 95% of cases.
Treatment
Treatment involves discontinuing the medication that caused the condition. Symptoms usually resolve within several weeks to months after the medication is stopped. In some cases, corticosteroids or nonsteroidal anti-inflammatory drugs (NSAIDs) may be used to manage symptoms.
See also
External links
- Medical encyclopedia article on Drug-induced lupus erythematosus
- Wikipedia's article - Drug-induced lupus erythematosus
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