Chlorphenoxamine

An article about the antihistamine drug Chlorphenoxamine

Chlorphenoxamine
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG

Chlorphenoxamine is a medication that belongs to the class of antihistamines. It is primarily used to treat allergic reactions and symptoms such as itching, runny nose, and sneezing.

Pharmacology

Chlorphenoxamine works by blocking the action of histamine, a substance in the body that causes allergic symptoms. It is a first-generation antihistamine, which means it can cross the blood-brain barrier and may cause sedation.

Uses

Chlorphenoxamine is used to relieve symptoms associated with allergic rhinitis, urticaria, and other allergic conditions. It may also be used as an adjunct in the treatment of anaphylaxis and angioedema.

Side Effects

Common side effects of chlorphenoxamine include drowsiness, dry mouth, and dizziness. Less common side effects may include blurred vision, constipation, and urinary retention.

Mechanism of Action

Chlorphenoxamine acts as an H1 receptor antagonist, preventing histamine from binding to its receptors and thereby reducing the symptoms of an allergic reaction. It also has mild anticholinergic properties, which contribute to its side effect profile.

History

Chlorphenoxamine was developed in the mid-20th century and has been used in various formulations for the treatment of allergic conditions. It is less commonly used today due to the availability of newer antihistamines with fewer side effects.

Related pages

• Antihistamine
• Allergic rhinitis
• Urticaria
• Anaphylaxis

• 
  Chlorphenoxamine