Acrivastine

An antihistamine used to treat allergies

Acrivastine
File:Acrivastine.svg
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Acrivastine is a second-generation antihistamine used to treat allergic rhinitis (such as hay fever) and urticaria (hives). It is known for its rapid onset of action and is often used in combination with pseudoephedrine to relieve nasal congestion.

Pharmacology

Acrivastine is a histamine H1 receptor antagonist, which means it works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Unlike first-generation antihistamines, acrivastine is less likely to cause drowsiness because it does not cross the blood-brain barrier as easily.

Medical uses

Acrivastine is primarily used for the relief of symptoms associated with allergic rhinitis and chronic urticaria. These symptoms include sneezing, runny nose, itchy eyes, and skin rash.

Side effects

Common side effects of acrivastine include headache, dry mouth, and drowsiness. Although it is less sedating than first-generation antihistamines, some patients may still experience drowsiness.

Contraindications

Acrivastine should not be used in individuals with severe kidney impairment or those who are hypersensitive to acrivastine or any of its components.

Interactions

Acrivastine may interact with other medications that cause drowsiness, such as alcohol, benzodiazepines, and other antihistamines. It is important to consult a healthcare provider before combining acrivastine with other medications.

Dosage

The typical dosage of acrivastine for adults and children over 12 years of age is 8 mg, taken up to three times a day. It is important to follow the prescribed dosage and not exceed the recommended amount.

Mechanism of action

Acrivastine works by selectively inhibiting the H1 receptor, which prevents histamine from binding to its receptor and causing allergic symptoms. This action helps alleviate the symptoms of allergies without significantly affecting the central nervous system.

Related pages

• Antihistamine
• Allergic rhinitis
• Urticaria
• Pseudoephedrine

Gallery

• Chemical structure of acrivastine
  Chemical structure of acrivastine