Lattice corneal dystrophy: Difference between revisions
From WikiMD's Wellness Encyclopedia
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{{Infobox medical condition | |||
| name = Lattice corneal dystrophy | |||
| image = [[File:Lattice_corneal_dystrophy_type_1.JPEG|left|thumb|Lattice corneal dystrophy type 1]] | |||
| caption = Slit lamp image of lattice corneal dystrophy type 1 | |||
| field = [[Ophthalmology]] | |||
| symptoms = [[Corneal opacity]], [[vision impairment]], [[eye pain]] | |||
| onset = Usually in [[childhood]] or [[early adulthood]] | |||
| duration = [[Chronic (medicine)|Chronic]] | |||
| causes = Genetic mutation in the [[TGFBI]] gene | |||
| risks = Family history of the condition | |||
| diagnosis = [[Slit lamp examination]], [[genetic testing]] | |||
| differential = [[Granular corneal dystrophy]], [[macular corneal dystrophy]] | |||
| treatment = [[Corneal transplant]], [[phototherapeutic keratectomy]] | |||
| prognosis = Variable, may lead to significant vision loss | |||
| frequency = Rare | |||
}} | |||
[[File:Lattice_corneal_dystrophy_type_II_diagram.gif|Lattice corneal dystrophy type II diagram|thumb|left]] | |||
'''Lattice corneal dystrophy''' is a rare, inherited disorder characterized by the abnormal accumulation of amyloid deposits in the cornea, the clear, outermost layer of the eye. It is named for the characteristic lattice-like pattern that the deposits form. | '''Lattice corneal dystrophy''' is a rare, inherited disorder characterized by the abnormal accumulation of amyloid deposits in the cornea, the clear, outermost layer of the eye. It is named for the characteristic lattice-like pattern that the deposits form. | ||
== Symptoms == | == Symptoms == | ||
The primary symptom of lattice corneal dystrophy is the presence of abnormal, lattice-like deposits in the cornea. These deposits can cause a variety of symptoms, including: | The primary symptom of lattice corneal dystrophy is the presence of abnormal, lattice-like deposits in the cornea. These deposits can cause a variety of symptoms, including: | ||
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* [[Corneal erosion]] (breakdown of the outermost layer of the cornea) | * [[Corneal erosion]] (breakdown of the outermost layer of the cornea) | ||
* [[Recurrent corneal erosion]] (repeated breakdown of the corneal surface) | * [[Recurrent corneal erosion]] (repeated breakdown of the corneal surface) | ||
== Causes == | == Causes == | ||
Lattice corneal dystrophy is caused by mutations in the [[TGFBI]] gene. This gene provides instructions for making a protein that is found in many tissues, including the cornea. Mutations in the TGFBI gene lead to the production of an abnormal protein that cannot be broken down properly, leading to the accumulation of amyloid deposits in the cornea. | Lattice corneal dystrophy is caused by mutations in the [[TGFBI]] gene. This gene provides instructions for making a protein that is found in many tissues, including the cornea. Mutations in the TGFBI gene lead to the production of an abnormal protein that cannot be broken down properly, leading to the accumulation of amyloid deposits in the cornea. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of lattice corneal dystrophy is typically made based on the characteristic appearance of the cornea under examination with a [[slit lamp]]. Genetic testing can also be used to confirm the diagnosis. | Diagnosis of lattice corneal dystrophy is typically made based on the characteristic appearance of the cornea under examination with a [[slit lamp]]. Genetic testing can also be used to confirm the diagnosis. | ||
== Treatment == | == Treatment == | ||
There is currently no cure for lattice corneal dystrophy. Treatment is focused on managing symptoms and may include: | There is currently no cure for lattice corneal dystrophy. Treatment is focused on managing symptoms and may include: | ||
* [[Artificial tears]] or ointments to relieve dryness and discomfort | * [[Artificial tears]] or ointments to relieve dryness and discomfort | ||
* [[Corneal transplantation]] in severe cases | * [[Corneal transplantation]] in severe cases | ||
== Prognosis == | == Prognosis == | ||
The prognosis for individuals with lattice corneal dystrophy varies. Some individuals may have mild symptoms and maintain good vision throughout their lives, while others may experience severe vision loss. | The prognosis for individuals with lattice corneal dystrophy varies. Some individuals may have mild symptoms and maintain good vision throughout their lives, while others may experience severe vision loss. | ||
== See also == | == See also == | ||
* [[Corneal dystrophy]] | * [[Corneal dystrophy]] | ||
* [[TGFBI]] | * [[TGFBI]] | ||
* [[Amyloidosis]] | * [[Amyloidosis]] | ||
[[Category:Eye diseases]] | [[Category:Eye diseases]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
{{Eye diseases}} | {{Eye diseases}} | ||
{{Rare diseases}} | {{Rare diseases}} | ||
{{Genetic disorders}} | {{Genetic disorders}} | ||
{{stub}} | {{stub}} | ||
Latest revision as of 04:11, 9 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD's medical weight loss NYC, sleep center NYC
Philadelphia medical weight loss and Philadelphia sleep clinics
| Lattice corneal dystrophy | |
|---|---|
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Corneal opacity, vision impairment, eye pain |
| Complications | N/A |
| Onset | Usually in childhood or early adulthood |
| Duration | Chronic |
| Types | N/A |
| Causes | Genetic mutation in the TGFBI gene |
| Risks | Family history of the condition |
| Diagnosis | Slit lamp examination, genetic testing |
| Differential diagnosis | Granular corneal dystrophy, macular corneal dystrophy |
| Prevention | N/A |
| Treatment | Corneal transplant, phototherapeutic keratectomy |
| Medication | N/A |
| Prognosis | Variable, may lead to significant vision loss |
| Frequency | Rare |
| Deaths | N/A |
Lattice corneal dystrophy is a rare, inherited disorder characterized by the abnormal accumulation of amyloid deposits in the cornea, the clear, outermost layer of the eye. It is named for the characteristic lattice-like pattern that the deposits form.
Symptoms[edit]
The primary symptom of lattice corneal dystrophy is the presence of abnormal, lattice-like deposits in the cornea. These deposits can cause a variety of symptoms, including:
- Blurred vision
- Photophobia (sensitivity to light)
- Eye pain
- Corneal erosion (breakdown of the outermost layer of the cornea)
- Recurrent corneal erosion (repeated breakdown of the corneal surface)
Causes[edit]
Lattice corneal dystrophy is caused by mutations in the TGFBI gene. This gene provides instructions for making a protein that is found in many tissues, including the cornea. Mutations in the TGFBI gene lead to the production of an abnormal protein that cannot be broken down properly, leading to the accumulation of amyloid deposits in the cornea.
Diagnosis[edit]
Diagnosis of lattice corneal dystrophy is typically made based on the characteristic appearance of the cornea under examination with a slit lamp. Genetic testing can also be used to confirm the diagnosis.
Treatment[edit]
There is currently no cure for lattice corneal dystrophy. Treatment is focused on managing symptoms and may include:
- Artificial tears or ointments to relieve dryness and discomfort
- Corneal transplantation in severe cases
Prognosis[edit]
The prognosis for individuals with lattice corneal dystrophy varies. Some individuals may have mild symptoms and maintain good vision throughout their lives, while others may experience severe vision loss.
See also[edit]
| Eye diseases and disorders | ||||||||||
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This eye diseases related article is a stub.
|
NIH genetic and rare disease info[edit]
Lattice corneal dystrophy is a rare disease.
| Rare and genetic diseases | ||||||
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Rare diseases - Lattice corneal dystrophy
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| Genetic disorders relating to deficiencies of transcription factor or coregulators | ||||||||||||||||||||||||||||||||||
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