Atypical depression: Difference between revisions
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{{Infobox medical condition | |||
| name = Atypical depression | |||
| image = [[File:Atypical_depression_diagram.png|250px]] | |||
| caption = Diagram illustrating the symptoms of atypical depression | |||
| field = [[Psychiatry]] | |||
| symptoms = [[Mood reactivity]], [[weight gain]], [[increased appetite]], [[hypersomnia]], [[leaden paralysis]], [[interpersonal rejection sensitivity]] | |||
| onset = Typically in [[adolescence]] or [[early adulthood]] | |||
| duration = Can be [[chronic]] or [[episodic]] | |||
| causes = [[Genetic]], [[environmental]], [[biological]] factors | |||
| risks = [[Family history of depression]], [[stressful life events]], [[chronic illness]] | |||
| diagnosis = [[Clinical assessment]], [[DSM-5]] criteria | |||
| differential = [[Major depressive disorder]], [[bipolar disorder]], [[dysthymia]], [[seasonal affective disorder]] | |||
| treatment = [[Cognitive behavioral therapy]], [[antidepressants]] (e.g., [[SSRIs]], [[MAOIs]]), [[lifestyle changes]] | |||
| prognosis = Varies; can improve with treatment | |||
| frequency = More common in [[females]] than [[males]] | |||
}} | |||
== Atypical Depression == | == Atypical Depression == | ||
[[File:Atypical_depression_diagram.png|left|thumb|Diagram illustrating atypical depression symptoms]] | |||
[[File:Atypical_depression_diagram.png|thumb | |||
'''Atypical depression''' is a subtype of [[major depressive disorder]] (MDD) characterized by mood reactivity and specific symptoms that differ from those of typical depression. Unlike typical depression, where mood is consistently low, individuals with atypical depression experience mood improvement in response to positive events. | '''Atypical depression''' is a subtype of [[major depressive disorder]] (MDD) characterized by mood reactivity and specific symptoms that differ from those of typical depression. Unlike typical depression, where mood is consistently low, individuals with atypical depression experience mood improvement in response to positive events. | ||
=== Symptoms === | === Symptoms === | ||
Atypical depression is distinguished by several key symptoms: | Atypical depression is distinguished by several key symptoms: | ||
* '''Mood reactivity''': The ability to feel better temporarily in response to positive events. | * '''Mood reactivity''': The ability to feel better temporarily in response to positive events. | ||
* '''Increased appetite or weight gain''': Unlike typical depression, where appetite is often reduced, individuals with atypical depression may experience increased appetite and subsequent weight gain. | * '''Increased appetite or weight gain''': Unlike typical depression, where appetite is often reduced, individuals with atypical depression may experience increased appetite and subsequent weight gain. | ||
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* '''Leaden paralysis''': A sensation of heaviness in the arms or legs. | * '''Leaden paralysis''': A sensation of heaviness in the arms or legs. | ||
* '''Interpersonal rejection sensitivity''': Heightened sensitivity to rejection or criticism, which can lead to significant social or occupational impairment. | * '''Interpersonal rejection sensitivity''': Heightened sensitivity to rejection or criticism, which can lead to significant social or occupational impairment. | ||
=== Diagnosis === | === Diagnosis === | ||
The diagnosis of atypical depression is made based on the presence of the above symptoms, in addition to meeting the criteria for major depressive disorder. It is important for clinicians to differentiate atypical depression from other mood disorders, such as [[bipolar disorder]] or [[dysthymia]]. | The diagnosis of atypical depression is made based on the presence of the above symptoms, in addition to meeting the criteria for major depressive disorder. It is important for clinicians to differentiate atypical depression from other mood disorders, such as [[bipolar disorder]] or [[dysthymia]]. | ||
=== Treatment === | === Treatment === | ||
Treatment for atypical depression often involves a combination of [[psychotherapy]] and [[pharmacotherapy]]. | Treatment for atypical depression often involves a combination of [[psychotherapy]] and [[pharmacotherapy]]. | ||
* '''Psychotherapy''': [[Cognitive behavioral therapy]] (CBT) is commonly used to help patients identify and change negative thought patterns and behaviors. | * '''Psychotherapy''': [[Cognitive behavioral therapy]] (CBT) is commonly used to help patients identify and change negative thought patterns and behaviors. | ||
* '''Pharmacotherapy''': [[Monoamine oxidase inhibitors]] (MAOIs) have been found to be particularly effective for atypical depression. However, due to dietary restrictions and side effects, they are often not the first line of treatment. [[Selective serotonin reuptake inhibitors]] (SSRIs) and [[serotonin-norepinephrine reuptake inhibitors]] (SNRIs) are also used. | * '''Pharmacotherapy''': [[Monoamine oxidase inhibitors]] (MAOIs) have been found to be particularly effective for atypical depression. However, due to dietary restrictions and side effects, they are often not the first line of treatment. [[Selective serotonin reuptake inhibitors]] (SSRIs) and [[serotonin-norepinephrine reuptake inhibitors]] (SNRIs) are also used. | ||
=== Prognosis === | === Prognosis === | ||
The prognosis for atypical depression varies. With appropriate treatment, many individuals experience significant improvement in symptoms. However, atypical depression can be chronic and may require long-term management. | The prognosis for atypical depression varies. With appropriate treatment, many individuals experience significant improvement in symptoms. However, atypical depression can be chronic and may require long-term management. | ||
== See also == | |||
== | |||
* [[Major depressive disorder]] | * [[Major depressive disorder]] | ||
* [[Bipolar disorder]] | * [[Bipolar disorder]] | ||
* [[Cognitive behavioral therapy]] | * [[Cognitive behavioral therapy]] | ||
* [[Monoamine oxidase inhibitor]] | * [[Monoamine oxidase inhibitor]] | ||
{{Mental health}} | {{Mental health}} | ||
[[Category:Depression (mood disorder)]] | [[Category:Depression (mood disorder)]] | ||
Latest revision as of 16:45, 4 April 2025

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Atypical depression | |
|---|---|
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Mood reactivity, weight gain, increased appetite, hypersomnia, leaden paralysis, interpersonal rejection sensitivity |
| Complications | N/A |
| Onset | Typically in adolescence or early adulthood |
| Duration | Can be chronic or episodic |
| Types | N/A |
| Causes | Genetic, environmental, biological factors |
| Risks | Family history of depression, stressful life events, chronic illness |
| Diagnosis | Clinical assessment, DSM-5 criteria |
| Differential diagnosis | Major depressive disorder, bipolar disorder, dysthymia, seasonal affective disorder |
| Prevention | N/A |
| Treatment | Cognitive behavioral therapy, antidepressants (e.g., SSRIs, MAOIs), lifestyle changes |
| Medication | N/A |
| Prognosis | Varies; can improve with treatment |
| Frequency | More common in females than males |
| Deaths | N/A |
Atypical Depression[edit]

Atypical depression is a subtype of major depressive disorder (MDD) characterized by mood reactivity and specific symptoms that differ from those of typical depression. Unlike typical depression, where mood is consistently low, individuals with atypical depression experience mood improvement in response to positive events.
Symptoms[edit]
Atypical depression is distinguished by several key symptoms:
- Mood reactivity: The ability to feel better temporarily in response to positive events.
- Increased appetite or weight gain: Unlike typical depression, where appetite is often reduced, individuals with atypical depression may experience increased appetite and subsequent weight gain.
- Hypersomnia: Excessive sleeping or sleeping more than usual, which contrasts with the insomnia often seen in typical depression.
- Leaden paralysis: A sensation of heaviness in the arms or legs.
- Interpersonal rejection sensitivity: Heightened sensitivity to rejection or criticism, which can lead to significant social or occupational impairment.
Diagnosis[edit]
The diagnosis of atypical depression is made based on the presence of the above symptoms, in addition to meeting the criteria for major depressive disorder. It is important for clinicians to differentiate atypical depression from other mood disorders, such as bipolar disorder or dysthymia.
Treatment[edit]
Treatment for atypical depression often involves a combination of psychotherapy and pharmacotherapy.
- Psychotherapy: Cognitive behavioral therapy (CBT) is commonly used to help patients identify and change negative thought patterns and behaviors.
- Pharmacotherapy: Monoamine oxidase inhibitors (MAOIs) have been found to be particularly effective for atypical depression. However, due to dietary restrictions and side effects, they are often not the first line of treatment. Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are also used.
Prognosis[edit]
The prognosis for atypical depression varies. With appropriate treatment, many individuals experience significant improvement in symptoms. However, atypical depression can be chronic and may require long-term management.