Neuropeptides B/W receptor 2

Neuropeptides B/W receptor 2 (NPBWR2), also known as G protein-coupled receptor 8 (GPR8), is a protein that in humans is encoded by the NPBWR2 gene. This receptor is a member of the ghrelin receptor family and is primarily expressed in the central nervous system (CNS).

Function

NPBWR2 is a receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, metabolism, and feeding behavior. The activation of NPBWR2 by its ligands leads to the stimulation of intracellular calcium release and synaptic transmission in the CNS.

Clinical significance

Alterations in the NPBWR2 gene have been associated with susceptibility to obesity and eating disorders. Further research is needed to fully understand the role of NPBWR2 in these conditions.

See also

• Neuropeptide
• G protein-coupled receptor
• Neuroendocrine system
• Obesity
• Eating disorders

References

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