OR2V2: Difference between revisions

OR2V2
Symbol	OR2V2
HGNC ID	14857
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	1q44.2
Locus supplementary data	–

Latest revision as of 20:30, 30 December 2024

OR2V2 is a gene that encodes a member of the olfactory receptor family of proteins. These receptors are involved in the detection of odor molecules and are a part of the G protein-coupled receptor (GPCR) superfamily. The OR2V2 gene is located on chromosome 1 in humans.

Function[edit]

Olfactory receptors, such as OR2V2, are responsible for the recognition and signal transduction of odorant molecules. These receptors are expressed in the olfactory epithelium and are crucial for the sense of smell. The OR2V2 protein interacts with odorant molecules in the nasal cavity, initiating a neuronal response that is transmitted to the olfactory bulb in the brain.

Structure[edit]

Like other olfactory receptors, OR2V2 has a characteristic 7-transmembrane domain structure, which is typical of GPCRs. This structure allows the receptor to span the cell membrane and interact with intracellular G proteins to transmit signals.

Genetic Information[edit]

The OR2V2 gene is part of a large family of olfactory receptor genes, which are the largest gene family in the human genome. These genes are highly diverse, allowing humans to detect a wide range of odors. The diversity of olfactory receptors is due to the presence of multiple alleles and gene duplications throughout evolution.

Clinical Significance[edit]

Variations in olfactory receptor genes, including OR2V2, can affect an individual's sense of smell. Some variations may lead to anosmia, the inability to perceive odor, while others may enhance olfactory sensitivity. Research into these genetic variations can provide insights into olfactory disorders and potential therapeutic targets.

References[edit]

External Links[edit]

[GeneCards: OR2V2](https://www.genecards.org/cgi-bin/carddisp.pl?gene=OR2V2)
[NCBI Gene: OR2V2](https://www.ncbi.nlm.nih.gov/gene/)

@@ Line 1: / Line 1: @@
-'''OR2V2''' is a gene that encodes the olfactory receptor, family 2, subfamily V, member 2 in humans. The [[olfactory receptor]] proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.
+{{Infobox gene
+| name = OR2V2
+| symbol = OR2V2
+| HGNCid = 14857
+| chromosome = 1
+| arm = q
+| band = 44.2
+}}
+'''OR2V2''' is a gene that encodes a member of the [[olfactory receptor]] family of proteins. These receptors are involved in the detection of odor molecules and are a part of the [[G protein-coupled receptor]] (GPCR) superfamily. The OR2V2 gene is located on [[chromosome 1]] in humans.
 == Function ==
+Olfactory receptors, such as OR2V2, are responsible for the recognition and [[signal transduction]] of odorant molecules. These receptors are expressed in the [[olfactory epithelium]] and are crucial for the sense of [[smell]]. The OR2V2 protein interacts with odorant molecules in the [[nasal cavity]], initiating a neuronal response that is transmitted to the [[olfactory bulb]] in the brain.
-The OR2V2 gene is part of the [[olfactory receptor]] gene family, which is the largest gene family in the human genome. The proteins encoded by these genes are responsible for the recognition and transduction of odorant signals, which are mediated by G proteins. The OR2V2 gene specifically encodes the olfactory receptor, family 2, subfamily V, member 2.
 == Structure ==
+Like other olfactory receptors, OR2V2 has a characteristic 7-transmembrane domain structure, which is typical of GPCRs. This structure allows the receptor to span the [[cell membrane]] and interact with intracellular [[G proteins]] to transmit signals.
-The OR2V2 gene is located on chromosome 19q13.2 and is composed of a single coding exon. The encoded protein is a member of the G-protein-coupled receptor 1 family and has 7 transmembrane domains, a characteristic structure of many neurotransmitter and hormone receptors.
+== Genetic Information ==
+The OR2V2 gene is part of a large family of olfactory receptor genes, which are the largest gene family in the human genome. These genes are highly diverse, allowing humans to detect a wide range of odors. The diversity of olfactory receptors is due to the presence of multiple [[alleles]] and [[gene duplications]] throughout evolution.
 == Clinical Significance ==
+Variations in olfactory receptor genes, including OR2V2, can affect an individual's sense of smell. Some variations may lead to [[anosmia]], the inability to perceive odor, while others may enhance olfactory sensitivity. Research into these genetic variations can provide insights into [[olfactory disorders]] and potential therapeutic targets.
-While the specific clinical significance of OR2V2 is not yet fully understood, olfactory receptors in general have been implicated in various diseases and conditions. For example, alterations in olfactory receptor function have been associated with anosmia, the inability to perceive odor. Additionally, olfactory receptors have been found to be expressed in a number of tissues outside of the olfactory system, suggesting potential roles in various physiological and pathological processes.
-[[File:OR2V2 gene location on human chromosome 19.png|thumb|right|300px|Location of the OR2V2 gene on human chromosome 19.]]
 == See Also ==
+* [[Olfactory system]]
-* [[Olfactory receptor]]
 * [[G protein-coupled receptor]]
-* [[Anosmia]]
+* [[Chromosome 1 (human)]]
 == References ==
+<references/>
+== External Links ==
+* [GeneCards: OR2V2](https://www.genecards.org/cgi-bin/carddisp.pl?gene=OR2V2)
+* [NCBI Gene: OR2V2](https://www.ncbi.nlm.nih.gov/gene/)
-{{Reflist}}
+{{Olfactory receptors}}
+{{G protein-coupled receptors}}
-[[Category:Genes on human chromosome 19]]
+[[Category:Olfactory receptors]]
 [[Category:G protein-coupled receptors]]
-[[Category:Olfactory system]]
+[[Category:Genes on human chromosome 1]]
-{{GPCR-stub}}
-{{medicine-stub}}