Lergotrile

Lergotrile is a medication that belongs to the class of drugs known as ergot alkaloids. It was developed by Sandoz, a Swiss pharmaceutical company, and is used in the treatment of Parkinson's disease and hyperprolactinemia.

Pharmacology

Lergotrile acts as an agonist at dopamine receptors, specifically the D2 subtype. This action is responsible for its therapeutic effects in Parkinson's disease and hyperprolactinemia. In addition to its dopaminergic activity, lergotrile also has serotonergic and adrenergic effects.

Clinical Use

Lergotrile is used in the treatment of Parkinson's disease, a neurodegenerative disorder characterized by the loss of dopamine-producing neurons in the substantia nigra. By acting as a dopamine receptor agonist, lergotrile can help to alleviate the motor symptoms of this disease.

In addition to its use in Parkinson's disease, lergotrile is also used to treat hyperprolactinemia, a condition characterized by abnormally high levels of prolactin in the blood. Lergotrile's dopaminergic activity can help to reduce prolactin levels and alleviate the symptoms of this condition.

Side Effects

Like all medications, lergotrile can cause side effects. These may include nausea, vomiting, dizziness, and orthostatic hypotension. In rare cases, lergotrile can cause pulmonary fibrosis, a serious lung disease.

See Also

• Ergot alkaloids
• Dopamine receptor agonists
• Parkinson's disease
• Hyperprolactinemia

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References

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External Links

• Lergotrile on Drugs.com
• Lergotrile on PubChem

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  Lergotrile