Hyoscine butylbromide: Difference between revisions

Hyoscine butylbromide
	File:Hyoscine butylbromide.svg
INN
Drug class
Routes of administration	Oral, intravenous, intramuscular, rectal
Pregnancy category
Bioavailability	Low
Metabolism	Hepatic
Elimination half-life	5 hours
Excretion	Renal
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG

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Revision as of 19:18, 22 March 2025

An antispasmodic medication used to treat crampy abdominal pain

Hyoscine butylbromide, also known as scopolamine butylbromide, is a medication used to treat abdominal pain associated with cramps and spasms of the gastrointestinal tract. It is commonly marketed under the brand name Buscopan.

Pharmacology

Hyoscine butylbromide is a quaternary ammonium compound derived from the plant Duboisia. It acts as an anticholinergic agent, specifically targeting the muscarinic acetylcholine receptors in the smooth muscle of the gastrointestinal tract. By inhibiting these receptors, hyoscine butylbromide reduces the muscle contractions that cause spasms and cramps.

Uses

Hyoscine butylbromide is primarily used to relieve abdominal pain and discomfort associated with cramps and spasms in the stomach and intestines. It is also used in the management of irritable bowel syndrome (IBS) and other conditions that involve gastrointestinal motility disorders.

Administration

Hyoscine butylbromide can be administered via several routes, including oral, intravenous, intramuscular, and rectal. The choice of administration depends on the severity of the symptoms and the clinical setting. For rapid relief, intravenous or intramuscular administration is preferred.

Side Effects

Common side effects of hyoscine butylbromide include dry mouth, dizziness, and blurred vision. These effects are due to its anticholinergic properties. Less common side effects include urinary retention, constipation, and tachycardia.

Contraindications

Hyoscine butylbromide is contraindicated in individuals with myasthenia gravis, megacolon, and narrow-angle glaucoma. Caution is advised in patients with prostatic hypertrophy and tachyarrhythmias.

Related pages

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-'''Hyoscine butylbromide''', also known as '''scopolamine butylbromide''' and sold under the brand name '''Buscopan''' among others, is an [[anticholinergic]] medication used to relieve crampy [[abdominal pain]], [[esophageal spasms]], [[renal colic]], and [[bladder spasms]].<ref name="BNF">{{cite book|title=British National Formulary (BNF) 74|year=2017|publisher=Pharmaceutical Press|isbn=978-0-85711-288-2}}</ref> In palliative care, it is used to improve respiratory secretions at the end of life.<ref name="twycross">{{cite book|last=Twycross|first=Robert|title=Palliative Care Formulary|year=2014|publisher=Palliativedrugs.com Ltd|isbn=978-0-9555019-6-2}}</ref>
+{{Short description|An antispasmodic medication used to treat crampy abdominal pain}}
-[[File:Butylscopolamine bromide structural formula V.1.svg|thumb|Butylscopolamine bromide structural formula V.1]]
+{{Drugbox
-==Medical Uses== <!--T:2-->
+| verifiedfields = changed
+| verifiedrevid = 477002679
+| IUPAC_name = (1S,3S,5R,6R,7S,9R,11S,12S,14R)-6,7,11,12-tetrahydroxy-9-(hydroxymethyl)-1,5,14-trimethyl-4-oxa-2-azoniatricyclo[8.3.1.0^{3,8}]tetradecane
+| image = Hyoscine butylbromide.svg
+| width = 200
+| tradename = Buscopan
+| pregnancy_AU = B2
+| pregnancy_category =
+| legal_AU = S3
+| legal_UK = P
+| legal_US = OTC
+| routes_of_administration = Oral, intravenous, intramuscular, rectal
+| bioavailability = Low
+| protein_bound = Low
+| metabolism = Hepatic
+| elimination_half-life = 5 hours
+| excretion = Renal
+}}
-Hyoscine butylbromide is used to treat a variety of conditions that involve spasms of smooth muscle, such as those found in the gastrointestinal tract, the biliary tract, the urinary tract, and the reproductive system.<ref name="BNF"/> It works by blocking the neurotransmitter acetylcholine in the nervous system, relaxing the smooth muscles.<ref>{{cite journal|last1=Gravitz|first1=L|title=A brief history of cognitive neuroscience|journal=Nature|year=2011|volume=474|issue=7351|pages=S20|doi=10.1038/474S20a|pmid=21677666}}</ref> This can reduce the severity of abdominal pain, bladder spasms, renal colic, and esophageal spasms.
+'''Hyoscine butylbromide''', also known as '''scopolamine butylbromide''', is a [[medication]] used to treat [[abdominal pain]] associated with [[cramps]] and [[spasms]] of the [[gastrointestinal tract]]. It is commonly marketed under the brand name '''Buscopan'''.
-In [[palliative care]], it is used to manage respiratory secretions in patients who are near the end of life.<ref name="twycross"/> By reducing secretions, it can help patients breathe more comfortably.
+==Pharmacology==
+Hyoscine butylbromide is a [[quaternary ammonium compound]] derived from the plant [[Duboisia]]. It acts as an [[anticholinergic]] agent, specifically targeting the [[muscarinic acetylcholine receptors]] in the [[smooth muscle]] of the [[gastrointestinal tract]]. By inhibiting these receptors, hyoscine butylbromide reduces the [[muscle contractions]] that cause [[spasms]] and [[cramps]].
-==Administration and Formulations== <!--T:3-->
+==Uses==
+Hyoscine butylbromide is primarily used to relieve [[abdominal pain]] and [[discomfort]] associated with [[cramps]] and [[spasms]] in the [[stomach]] and [[intestines]]. It is also used in the management of [[irritable bowel syndrome]] (IBS) and other conditions that involve [[gastrointestinal motility disorders]].
-Hyoscine butylbromide can be administered in various ways, including by mouth, injection into a muscle, or into a vein.<ref name="BNF"/> It is available as oral tablets, rectal suppositories, and injectable formulations.<ref name="BNF"/>
+==Administration==
+Hyoscine butylbromide can be administered via several routes, including [[oral]], [[intravenous]], [[intramuscular]], and [[rectal]]. The choice of administration depends on the severity of the symptoms and the clinical setting. For rapid relief, intravenous or intramuscular administration is preferred.
-In the United States, hyoscine butylbromide is approved for use in horses but not in humans.<ref>{{cite web|title=Buscopan Injectable Solution|url=https://www.drugs.com/vet/buscopan-injectable-solution-can.html|publisher=Drugs.com|accessdate=2018-12-07}}</ref> In contrast, it is widely used in human medicine in many other countries.
+==Side Effects==
+Common side effects of hyoscine butylbromide include [[dry mouth]], [[dizziness]], and [[blurred vision]]. These effects are due to its anticholinergic properties. Less common side effects include [[urinary retention]], [[constipation]], and [[tachycardia]].
-==Safety and Contraindications== <!--T:4-->
+==Contraindications==
+Hyoscine butylbromide is contraindicated in individuals with [[myasthenia gravis]], [[megacolon]], and [[narrow-angle glaucoma]]. Caution is advised in patients with [[prostatic hypertrophy]] and [[tachyarrhythmias]].
-Hyoscine butylbromide is generally well-tolerated, but it may cause side effects such as dry mouth, blurred vision, and urinary retention.<ref name="BNF"/> These effects result from its anticholinergic action. It is contraindicated in patients with glaucoma, severe ulcerative colitis, myasthenia gravis, and certain types of blockage in the gastrointestinal or urinary tract.<ref name="BNF"/>
-== See Also == <!--T:5-->
+==Related pages==
 * [[Anticholinergic]]
-* [[Abdominal pain]]
+* [[Gastrointestinal tract]]
-* [[Esophageal spasms]]
+* [[Irritable bowel syndrome]]
-* [[Renal colic]]
+* [[Muscarinic acetylcholine receptor]]
-* [[Bladder spasms]]
-{{stub}}
-==References== <!--T:6-->
-<references />
+[[Category:Antispasmodics]]
-[[Category:World Health Organization essential medicines]]
+[[Category:Anticholinergics]]
-[[Category:Muscarinic antagonists]]
+[[Category:Quaternary ammonium compounds]]
-[[Category:Tropane alkaloids]]