OR2T11

OR2T11 is a gene that encodes a protein in the olfactory receptor family. This family is responsible for the detection of odorants, and is the largest gene superfamily in mammals. The olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell.

The OR2T11 gene is located on chromosome 1, specifically at 1q44. It is a member of the olfactory receptor family 2, subfamily T, and is referred to as member 11.

Function

The protein encoded by the OR2T11 gene is an olfactory receptor. Olfactory receptors are members of the G protein-coupled receptor superfamily. They are involved in the detection of odorants in the nasal cavity. These receptors are responsible for the sense of smell.

Structure

The OR2T11 gene is composed of a single exon and spans approximately 1 kilobase. The encoded protein is a 7-transmembrane receptor, typical of G protein-coupled receptors.

Expression

OR2T11 is expressed in the olfactory epithelium, where it is involved in odorant recognition.

Clinical Significance

While the specific clinical significance of OR2T11 is not yet fully understood, olfactory receptors in general have been implicated in various diseases and conditions. For example, alterations in the sense of smell can be an early sign of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Neurodegenerative diseases

References

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