Sheehan's syndrome

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Sheehan's syndrome
Synonyms	Postpartum pituitary gland failure
Pronounce	N/A
Specialty	N/A
Symptoms	Fatigue, hypotension, hypoglycemia, amenorrhea, lactation failure
Complications	Adrenal crisis, hypothyroidism, infertility
Onset	After childbirth
Duration	Long-term
Types	N/A
Causes	Severe blood loss and hypovolemic shock during or after childbirth
Risks	Obstetric hemorrhage, multiple pregnancies, prolonged labor
Diagnosis	MRI, hormone level tests
Differential diagnosis	Lymphocytic hypophysitis, pituitary apoplexy, empty sella syndrome
Prevention	N/A
Treatment	Hormone replacement therapy
Medication	Corticosteroids, thyroid hormone, estrogen, growth hormone
Prognosis	Good with treatment
Frequency	Rare
Deaths	Rare

Sheehan's syndrome, also known as postpartum pituitary gland necrosis, is hypopituitarism (decreased functioning of the pituitary gland), caused by ischemic necrosis due to blood loss and hypovolemic shock during and after childbirth.<ref>,

 First aid for the obstetrics & gynecology clerkship, 
  
 McGraw-Hill Professional, 
  
  
  
 ISBN 9780071634199,</ref>

Signs and symptoms

The various signs and symptoms in Sheehan's syndrome are caused by damage to the pituitary, thereby causing a decrease in one or more of the hormones it normally secretes. Because the pituitary controls many glands in the endocrine system, partial or complete loss of a variety of functions may result.<ref name=":4" /> The most common initial symptoms of Sheehan's syndrome are agalactorrhea (absence of lactation) and/or difficulties with lactation.<ref name="Schrager_2001">,

 Sheehan syndrome: a rare complication of postpartum hemorrhage, 
 The Journal of the American Board of Family Practice, 
 
 Vol. 14(Issue: 5),
 pp. 389–91,
 
 PMID: 11572546,
 
 
 Full text,</ref> Many women also report amenorrhea or oligomenorrhea after delivery.<ref name="Schrager_2001" /> In some cases, a woman with Sheehan syndrome is relatively asymptomatic; therefore, the diagnosis would not be made until years later, with features of hypopituitarism.<ref name="Schrager_2001" /> Such features include secondary hypothyroidism (hypothyroidism due to pituitary dysfunction) with tiredness, intolerance to cold, constipation, weight gain, hair loss and slowed thinking, as well as a slowed heart rate and low blood pressure. Another such feature is secondary adrenal insufficiency (lack of ACTH secretion from the anterior pituitary). In a more chronic case, it is similar to Addison's disease with symptoms including fatigue, weight loss, hypoglycemia (low blood sugar levels), anemia and hyponatremia (low sodium levels). Such a patient may become acutely exacerbated when her body is stressed by a severe infection or surgery years after her delivery: a condition equivalent with an Addisonian crisis.<ref name="Schrager_2001" /> The symptoms of adrenal crisis should be treated immediately and can be life-threatening.<ref>

Addison's disease - Symptoms and causes(link). Mayo Clinic.

Accessed 2019-04-29.

</ref> Gonadotropin deficiency will often cause amenorrhea, oligomenorrhea, hot flashes, or decreased libido.<ref name="Schrager_2001" /> Cessation of menses is an important indicator of Gonadotropin deficiency as a result of Sheehan’s syndrome.<ref name="Shivaprasad_2011">,

 Sheehan's syndrome: Newer advances, 
 Indian Journal of Endocrinology and Metabolism, 
 
 Vol. 15 Suppl 3(Issue: 7),
 pp. S203-7,
 DOI: 10.4103/2230-8210.84869,
 PMID: 22029025,
 PMC: 3183525,</ref> Growth hormone deficiency causes many vague symptoms including fatigue and decreased muscle mass.<ref name="Schrager_2001" />

Growth-hormone deficiency is the most common symptom of hypopituitarism seen in Sheehan‚Äôs syndrome with a 90–100% occurrence seen in the Netherlands, Costa Rica, and Saudi Arabia. In these populations the occurrence of Cortisol, TSH, and gonadotropin deficiencies ranges from 50 to 100%.<ref name="Shivaprasad_2011" /> Hematological changes may occur due to a decrease in erythropoietin synthesis as a result of these cortisol and thyroid hormone decreases.<ref name="Karaca_2016">,

 Sheehan syndrome, 
 Nature Reviews. Disease Primers, 
 
 Vol. 2,
 pp. 16092,
 DOI: 10.1038/nrdp.2016.92,
 PMID: 28004764,</ref>

Uncommonly, Sheehan syndrome may also appear acutely after delivery, mainly by hyponatremia.<ref name="Schrager_2001" /> Electrolytic imbalances might result from the increased secretion of ADH, which may be caused by a decrease in blood pressure due to lower glucocorticoid deficiency. There are several possible mechanisms by which hypopituitarism can result in hyponatremia, including decreased free-water clearance by hypothyroidism, direct syndrome of inappropriate antidiuretic hormone (ADH) hypersecretion, decreased free-water clearance by glucocorticoid deficiency (independent of ADH).<ref name="Schrager_2001" /> Serum potassium levels, however, will not change due to Sheehan’s syndrome. This is because potassium levels are primarily regulated independently from the pituitary gland (the renin-angiotensin-aldosterone system begins in the kidney).<ref name = "Aiguo_2007">Aiguo, Wu,

 PMID Observer Design of Descriptor Linear Systems, 
 2007 Chinese Control Conference, 
 
 
 pp. 161–165,
 DOI: 10.1109/chicc.2006.4347343,</ref>

Causes

In the developed world Sheehan’s Syndrome is a rare complication of pregnancy, usually manifesting after excessive blood loss after delivery. The presence of disseminated intravascular coagulation (i.e., in amniotic fluid embolism or HELLP syndrome) also appears to be a factor in its development. A retrospective study in Turkey found that the prevalence of Sheehan’s syndrome was directly proportional to the amount of at-home deliveries each decade.<ref name="Shivaprasad_2011" /> This may be due to previously limited obstetric techniques present in a home environment. For example, an area of improvement in preventing the condition could be the an increase in the efficacy of treatment to hypovolemic shock through blood transfusion.<ref name="Karaca_2016" /> Pituitary necrosis may directly result from a lack of blood flow in the hypophyseal artery as a result of pituitary gland enlargement during pregnancy.<ref name=":4">Keleştimur, Fahrettin,

 Sheehan's Syndrome, 
 Pituitary, 
 
 Vol. 6(Issue: 4),
 pp. 181–188,
 DOI: 10.1023/B:PITU.0000023425.20854.8e,</ref> One cause of pituitary growth associated with the risk of Sheehan’s syndrome is the hyperplasia of lactotrophs (responsible for prolactin production).<ref name = "Aiguo_2007" /> Ischemia may occur as a result of vasospasm, thrombosis, or vascular compression sometimes as a result of an increase in the amount of lactotroph cells throughout gestation (contributing to the enlargement of the pituitary gland).<ref name="Karaca_2016" /> Necrosis may occur as a result of severe hypotension or shock due to excessive uterine bleeding following childbirth.<ref name="Karaca_2016" /> Sheehan’s syndrome may occur as a result of the arterial constriction and abnormal hypotension in conjunction with an insufficiency to meet the increased demand in blood supply of the pituitary gland seen during pregnancy.<ref name="Karaca_2016" /> This increased blood-flow and metabolic demand is associated with the previously mentioned hyperplasia of lactotrophs.<ref name = "Aiguo_2007" />

Some possible predisposing factors to Sheehan’s syndrome may include: inherited or acquired disseminated blood coagulation (DIC), restriction pituitary blood supply, small sella size, vasospasm, or thrombosis.<ref name="Karaca_2016" /> Post-Partum Hemorrhaging (PPH) is believed to be a predictor of Sheehan’s syndrome, so the symptoms of anaemia, obesity, and advanced maternal age may increase the risk of Sheehan Syndrome.<ref name="Karaca_2016" /> Atony of the uterus may be related to PPH that could induce Sheehan’s syndrome. This results in the abnormally prolonged flow of blood to the placenta after delivery.<ref name="Karaca_2016" />

Pathophysiology

Sheehan's syndrome is caused by damage to the pituitary, thereby causing a decrease in one or more of the hormones it normally secretes. The anterior pituitary is supplied by a low pressure portal venous system.<ref name="Karaca_2016" /> A 1995 study found that 56.2% of patients with diagnosed Sheehan’s syndrome experienced a loss of all pituitary hormones (with the remaining 43.8% having selective pituitary insufficiency). Since the growth hormone-secreting cells are located at the periphery of the pituitary (and are therefore most likely to be affected by ischemia), all of the patients experienced growth hormone deficiency.<ref name="Shivaprasad_2011" />

Diagnosis

Hormonal assays are conducted to determine a patient has low levels of T4, TSH, estrogen, gonadotropin, cortisol, and ACTH depending on the extent of necrosis.<ref name="Shivaprasad_2011" /> It might be difficult to detect damage to these hormone pathways if hormone levels are at the borderline of the abnormal range. In this case, stimulation tests will be done to determine if the pituitary is responsive to hypothalamic hormones.<ref name="Karaca_2016" /> For example, to determine deficiencies in cortisol release, synthetic ACTH might be administered, and hormonal assays will be conducted to determine the strength of the response. Additionally, MRI of the pituitary and hypothalamus: this helps to exclude tumor or other pathologies. ^{(August 2020)}

Treatment

Lifelong hormone replacement therapy for the hormones that are missing.<ref name = "Errarhay_2009">,

 Sheehan's Syndrome A Case Report and Literature Review, 
 The Libyan Journal of Medicine, 
 
 Vol. 4(Issue: 2),
 pp. 81–2,
 DOI: 10.4176/081201,
 PMID: 21483515,
 PMC: 3066722,</ref> This may involve treatment with glucocorticoids. After hormone profiling, treatment with cortisol, ACTH, thyroid hormones, gonadotropins, and prolactin as seen in cases of hypopituitarism may occur.<ref name = "Errarhay_2009" />

Epidemiology

In a study of 1,034 symptomatic adults, Sheehan’s syndrome was found to be the sixth-most frequent etiology of growth hormone deficiency, being responsible for 3.1% of cases (versus 53.9% due to a pituitary tumor).<ref name="Shivaprasad_2011" /> Sheehan syndrome is more prevalent in developing countries than developed countries.<ref name="Karaca_2016" /> Additionally, it was found that the majority of women who experienced Sheehan syndrome gave birth at home rather than in a hospital.<ref name="Karaca_2016" />

History

The specific association with postpartum shock or hemorrhage was described in 1937 by the British pathologist Harold Leeming Sheehan (1900–1988).<ref>,

 The Repair of Post-Partum Necrosis of the Anterior Lobe of the Pituitary Gland, 
 Acta Endocrinologica, 
 
 Vol. 48(Issue: 1),
 pp. 40–60,
 DOI: 10.1530/acta.0.0480040,</ref> The initial distinction was made in the research article “Post-Partum Necrosis of the Anterior Pituitary”.<ref name="Sheehan_1937">, 
 Post-partum necrosis of the anterior pituitary, 
 The Journal of Pathology and Bacteriology, 
 
 Vol. 45(Issue: 1),
 pp. 189–214,
 DOI: 10.1002/path.1700450118,</ref> In his research, Dr. Sheehan reviewed (through autopsy) the effects of pituitary necrosis on 12 cases of patient’s that experienced postpartum necrosis.<ref name="Sheehan_1937" /> He observed cases where lesions and death occurred during or after pregnancy, as well as cases where death occurred in the late stage of necrosis (years later). This started the initial distinction of Sheehan’s syndrome from Simmonds’ disease (also known as hypopituitarism). Dr. Sheehan noted that significant features of these patient cases was hemorrhaging, which in his experience was most commonly caused by either: placenta Previa (low placenta), uterine rupture, cervical or uterine tears, post-partum atony, or retained placenta. Simmonds' disease, however, occurs in either sex due to causes unrelated to pregnancy.<ref name="Karaca_2016" />

However, in his 1939 publication: “Simmonds’ Disease due to Post-partum Necrosis of the Anterior Pituitary”, Dr. Sheehan displays post-partum necrosis as a cause of Simmonds’ disease, thus establishing the relationship between the two conditions.<ref>,

 Simmonds's Disease due to Post-partum Necrosis of Anterior Pituitary, 
 British Medical Journal, 
 
 Vol. 2(Issue: 4423),
 pp. 493–4,
 DOI: 10.1093/oxfordjournals.qjmed.a069138,
 PMID: 20786336,
 PMC: 2059949,</ref> According to Sheehan in 1939 approximately 41% of survivors of severe postpartum hemorrhage (PPH) and/or hypovolemic shock experienced severe or partial hypopituitarism.<ref name="Karaca_2016" />

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