Piroheptine: Difference between revisions
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{{Short description|An anticholinergic drug used in the treatment of Parkinson's disease}} | |||
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| image = Piroheptine.png | |||
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| image_alt = Chemical structure of Piroheptine | |||
| image_caption = Chemical structure of Piroheptine | |||
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== | '''Piroheptine''' is a [[pharmacological]] agent classified as an [[anticholinergic]] drug. It is primarily used in the management of [[Parkinson's disease]], a [[neurodegenerative disorder]] characterized by [[tremor]], [[rigidity]], and [[bradykinesia]]. | ||
Piroheptine | |||
==Mechanism of Action== | |||
Piroheptine functions by inhibiting the action of [[acetylcholine]], a [[neurotransmitter]] involved in the regulation of [[motor control]]. By blocking acetylcholine receptors, piroheptine helps to restore the balance between acetylcholine and [[dopamine]] in the [[central nervous system]], which is often disrupted in Parkinson's disease. | |||
==Pharmacokinetics== | |||
Piroheptine is administered [[orally]] and is absorbed through the [[gastrointestinal tract]]. It undergoes [[hepatic metabolism]] and is excreted primarily through the [[renal system]]. The drug has a moderate [[half-life]], allowing for dosing multiple times a day to maintain therapeutic levels. | |||
==Clinical Use== | ==Clinical Use== | ||
Piroheptine is | Piroheptine is indicated for the treatment of [[Parkinsonian syndromes]], including idiopathic Parkinson's disease and drug-induced parkinsonism. It is often used in combination with other [[antiparkinsonian agents]] such as [[levodopa]] to enhance therapeutic outcomes. | ||
==Side Effects== | ==Side Effects== | ||
Common side effects of piroheptine include [[dry mouth]], [[constipation]], [[urinary retention]], and [[blurred vision]]. These effects are typical of anticholinergic drugs due to their action on the [[parasympathetic nervous system]]. | |||
== | ==Contraindications== | ||
Piroheptine is contraindicated in patients with [[glaucoma]], [[prostatic hypertrophy]], and [[obstructive gastrointestinal disorders]]. Caution is advised in elderly patients due to the increased risk of [[cognitive impairment]]. | |||
== | ==Related pages== | ||
* ' | * [[Parkinson's disease]] | ||
* | * [[Anticholinergic]] | ||
* [[Neurotransmitter]] | |||
* [[Dopamine]] | |||
[[Category: | [[Category:Anticholinergic drugs]] | ||
[[Category: | [[Category:Parkinson's disease treatments]] | ||
<gallery> | |||
File:Piroheptine.png|Piroheptine | |||
</gallery> | |||
Latest revision as of 01:42, 20 February 2025
An anticholinergic drug used in the treatment of Parkinson's disease
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Piroheptine is a pharmacological agent classified as an anticholinergic drug. It is primarily used in the management of Parkinson's disease, a neurodegenerative disorder characterized by tremor, rigidity, and bradykinesia.
Mechanism of Action[edit]
Piroheptine functions by inhibiting the action of acetylcholine, a neurotransmitter involved in the regulation of motor control. By blocking acetylcholine receptors, piroheptine helps to restore the balance between acetylcholine and dopamine in the central nervous system, which is often disrupted in Parkinson's disease.
Pharmacokinetics[edit]
Piroheptine is administered orally and is absorbed through the gastrointestinal tract. It undergoes hepatic metabolism and is excreted primarily through the renal system. The drug has a moderate half-life, allowing for dosing multiple times a day to maintain therapeutic levels.
Clinical Use[edit]
Piroheptine is indicated for the treatment of Parkinsonian syndromes, including idiopathic Parkinson's disease and drug-induced parkinsonism. It is often used in combination with other antiparkinsonian agents such as levodopa to enhance therapeutic outcomes.
Side Effects[edit]
Common side effects of piroheptine include dry mouth, constipation, urinary retention, and blurred vision. These effects are typical of anticholinergic drugs due to their action on the parasympathetic nervous system.
Contraindications[edit]
Piroheptine is contraindicated in patients with glaucoma, prostatic hypertrophy, and obstructive gastrointestinal disorders. Caution is advised in elderly patients due to the increased risk of cognitive impairment.
Related pages[edit]
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Piroheptine
