Clidinium bromide: Difference between revisions

Clidinium bromide
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Latest revision as of 11:33, 15 February 2025

An anticholinergic drug used to treat peptic ulcers and other gastrointestinal disorders

Clidinium bromide is an anticholinergic drug that is used in combination with other medications to treat peptic ulcers and other gastrointestinal disorders. It is often combined with chlordiazepoxide in a formulation known as Librax.

Pharmacology[edit]

Clidinium bromide works by reducing the secretions of certain organs in the body. It is an anticholinergic agent, which means it blocks the action of the neurotransmitter acetylcholine in the central nervous system and peripheral nervous system. This action helps to decrease the muscle spasms in the gastrointestinal tract and reduce the production of stomach acid.

Medical uses[edit]

Clidinium bromide is primarily used to treat:

Side effects[edit]

Common side effects of clidinium bromide include:

Less common side effects may include:

Contraindications[edit]

Clidinium bromide should not be used in individuals with:

Mechanism of action[edit]

Clidinium bromide exerts its effects by blocking the muscarinic acetylcholine receptors in the smooth muscle of the gastrointestinal tract. This leads to a reduction in muscle spasms and a decrease in the secretion of stomach acids.

History[edit]

Clidinium bromide was first introduced in the 1960s and has been used in combination with other medications to treat various gastrointestinal disorders. Its combination with chlordiazepoxide, a benzodiazepine, is particularly popular for its dual action of reducing anxiety and gastrointestinal symptoms.

Related pages[edit]

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-'''Clidinium bromide''' is a synthetic [[anticholinergic]] agent with [[antispasmodic]] properties. It is used in the treatment of [[gastrointestinal disorders]] such as [[peptic ulcer disease]] and [[irritable bowel syndrome]].
+{{Short description|An anticholinergic drug used to treat peptic ulcers and other gastrointestinal disorders}}
+{{Drugbox
+| verifiedfields = changed
+| verifiedrevid = 477002123
+| image = Clidinium_bromide.svg
+| image2 = <!-- Another image if available -->
+}}
-== Pharmacology ==
+'''Clidinium bromide''' is an [[anticholinergic]] drug that is used in combination with other medications to treat [[peptic ulcer]]s and other [[gastrointestinal]] disorders. It is often combined with [[chlordiazepoxide]] in a formulation known as [[Librax]].
-Clidinium bromide works by decreasing the secretion of fluids in the stomach and intestines, and slowing the natural movements of the gut. This helps to reduce cramping and improve the symptoms of gastrointestinal disorders.
+==Pharmacology==
+Clidinium bromide works by reducing the secretions of certain organs in the body. It is an anticholinergic agent, which means it blocks the action of the neurotransmitter [[acetylcholine]] in the [[central nervous system]] and [[peripheral nervous system]]. This action helps to decrease the muscle spasms in the [[gastrointestinal tract]] and reduce the production of stomach acid.
-== Uses ==
+==Medical uses==
+Clidinium bromide is primarily used to treat:
+* [[Peptic ulcer]]s
+* [[Irritable bowel syndrome]] (IBS)
+* [[Gastroesophageal reflux disease]] (GERD)
+* [[Spastic colon]]
-Clidinium bromide is primarily used in the treatment of [[gastrointestinal disorders]]. It is often combined with other medications, such as [[chlordiazepoxide]], to treat conditions like [[irritable bowel syndrome]] and [[peptic ulcer disease]].
+==Side effects==
+Common side effects of clidinium bromide include:
+* [[Dry mouth]]
+* [[Blurred vision]]
+* [[Constipation]]
+* [[Drowsiness]]
-== Side Effects ==
+Less common side effects may include:
+* [[Urinary retention]]
+* [[Tachycardia]]
+* [[Confusion]]
-Common side effects of clidinium bromide include dry mouth, blurred vision, and constipation. More serious side effects can include confusion, fast heart rate, and difficulty urinating.
+==Contraindications==
+Clidinium bromide should not be used in individuals with:
+* [[Glaucoma]]
+* [[Myasthenia gravis]]
+* [[Prostatic hypertrophy]]
-== Contraindications ==
+==Mechanism of action==
+Clidinium bromide exerts its effects by blocking the [[muscarinic acetylcholine receptors]] in the [[smooth muscle]] of the [[gastrointestinal tract]]. This leads to a reduction in muscle spasms and a decrease in the secretion of stomach acids.
-Clidinium bromide should not be used in patients with [[glaucoma]], [[myasthenia gravis]], or a history of urinary retention. It should also be used with caution in elderly patients, as they may be more susceptible to the side effects of the medication.
+==History==
+Clidinium bromide was first introduced in the 1960s and has been used in combination with other medications to treat various gastrointestinal disorders. Its combination with chlordiazepoxide, a [[benzodiazepine]], is particularly popular for its dual action of reducing anxiety and gastrointestinal symptoms.
-== Interactions ==
-Clidinium bromide can interact with a number of other medications, including [[antidepressants]], [[antihistamines]], and [[antipsychotics]]. These interactions can increase the risk of side effects and decrease the effectiveness of the medication.
-== See Also ==
+==Related pages==
 * [[Anticholinergic]]
-* [[Antispasmodic]]
-* [[Gastrointestinal disorders]]
 * [[Peptic ulcer disease]]
 * [[Irritable bowel syndrome]]
+* [[Gastroesophageal reflux disease]]
-[[Category:Pharmacology]]
+[[Category:Anticholinergic agents]]
-[[Category:Medicine]]
+[[Category:Gastrointestinal drugs]]
-[[Category:Gastroenterology]]
-{{pharma-stub}}
-{{medicine-stub}}