Ticarcillin

Information about Ticarcillin

Ticarcillin is an extended-spectrum carboxypenicillin antibiotic and is used to treat moderate-to-severe infections due to susceptible organisms.

Liver safety of Ticarcillin

Ticarcillin has been linked with idiosyncratic liver injury, but only rarely and as isolated case reports.

Mechanism of action of Ticarcillin

Ticarcillin (tye" kar sil' in) is a fourth generation, extended-spectrum penicillin antibiotic which is used for moderate-to-severe infections caused by susceptible gram positive and gram negative agents.

• The extended spectrum of ticarcillin makes it an appropriate agent in therapy of Pseudomonas aeruginosa.

• Ticarcillin also has extended activity against some Enterobacter and Proteus species.

• Ticarcillin has activity against most of the agents that are sensitive to natural penicillins, but is often less active. Ticarcillin is resistant to inactivation by many, but not all beta-lactamases.

Dosage and administration for Ticarcillin

Ticarcillin is available in parenteral forms generically and under the name Ticar and is usually given in doses of 200 to 300 mg/kg per day in divided doses intravenously every 4 to 6 hours. Currently it is almost always given in combination with clavunalic acid to increase efficacy against beta-lactamase producing penicillin-resistant bacteria.

Side effects of Ticarcillin

Common side effects include nausea, diarrhea, dizziness, headache, rash and hypersensitivity reactions.

Penicillin antibiotics

• penicillins first generation (natural penicillins)
  • benzathine penicillin, procaine penicillin, penicillin g, penicillin v, penicillin vk

• penicillins second generation (penicillinase-resistant penicillins)
  • cloxacillin, dicloxacillin, flucloxacillin, methicillin, nafcillin, oxacillin

• penicillins third generation (aminopenicillins)
  • amoxicillin, ampicillin, ampicillin-sulbactam, bacampicillin, pivampicillin
• see also amoxicillin-clavulanate

• penicillins fourth generation (extended-spectrum penicillins)
  • carbenicillin, mezlocillin, piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate

• Dailymed label info on Ticarcillin
• FDA Ticarcillin

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  Ticarcillin
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  Ticarcillin synthesis