Pregnenolone (medication)

Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such, it is a prohormone. Pregnenolone is a GABA-A receptor antagonist and contributes to enhanced neurological function.

Pharmacology

Pregnenolone and its sulfate, like DHEA and its sulfate, belong to the group of neurosteroids that are found in high concentrations in certain areas of the brain, and are synthesized there. Neurosteroids affect synaptic functioning, are neuroprotective, and enhance myelinization. Pregnenolone and its sulfate ester are under investigation for their potential to improve cognitive and memory functioning.

Medical uses

Pregnenolone is used in the treatment of fatigue, Alzheimer's disease, trauma, and injuries. It is also used in the treatment of skin disorders, including psoriasis and scleroderma.

Side effects

Potential side effects of pregnenolone may include irritability, anxiety, and insomnia. Long-term effects of pregnenolone are not known.

Pharmacokinetics

Pregnenolone is lipophilic and is believed to cross the blood-brain barrier.

References

External links

Pregnenolone.net

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