Phenacyl chloride

Chloroacetophenone.svg

Phenacyl chloride is an organic compound with the chemical formula C₈H₇ClO. It is a colorless to pale yellow liquid with a pungent odor. Phenacyl chloride is primarily used in the synthesis of various chemical compounds and has applications in the field of organic chemistry.

Chemical Structure and Properties

Phenacyl chloride consists of a benzene ring attached to a carbonyl group (C=O) and a chlorine atom. The presence of the carbonyl group makes it a reactive compound, particularly in nucleophilic substitution reactions.

• Molecular formula: C₈H₇ClO
• Molar mass: 154.59 g/mol
• Appearance: Colorless to pale yellow liquid
• Density: 1.22 g/cm³
• Boiling point: 232 °C (450 °F)
• Melting point: -1 °C (30 °F)

Synthesis

Phenacyl chloride can be synthesized through the Friedel-Crafts acylation of benzene with chloroacetyl chloride in the presence of a Lewis acid catalyst such as aluminum chloride (AlCl₃).

Applications

Phenacyl chloride is used in the synthesis of various pharmaceuticals, pesticides, and other organic compounds. It is also employed as a reagent in chemical research and organic synthesis.

Safety and Handling

Phenacyl chloride is a hazardous chemical and should be handled with care. It is a strong irritant to the skin, eyes, and respiratory system. Proper personal protective equipment (PPE) such as gloves, goggles, and lab coats should be worn when handling this compound. In case of contact, affected areas should be rinsed thoroughly with water.

Related Compounds

• Benzoyl chloride
• Acetyl chloride
• Chloroacetyl chloride

See Also

• Organic chemistry
• Nucleophilic substitution
• Friedel-Crafts acylation