Metizolam

Metizolam (marketed under the brand name Tranzilam) is a thienodiazepine drug which is a benzodiazepine analog. The effects of metizolam include anxiolytic, drowsiness, muscle relaxation, and amnesia which are typical of such drugs.

Pharmacology

Metizolam has been found to be roughly the same potency as diazepam, but with a slightly longer half-life. It is metabolized in the liver into the active metabolite alpha-hydroxymetizolam.

Medical Uses

Metizolam is used for the short-term treatment of insomnia, anxiety, and panic disorder. It is also used as a premedication for minor surgical procedures.

Side Effects

Common side effects of metizolam include drowsiness, dizziness, nausea, and dry mouth. More serious side effects may include respiratory depression, dependence, and withdrawal syndrome.

Interactions

Metizolam may interact with other medications, including other CNS depressants, alcohol, and grapefruit juice. These interactions can increase the risk of side effects and should be avoided.

Legal Status

In many countries, metizolam is a controlled substance due to its potential for abuse and dependence.

See Also

• Benzodiazepine
• Thienodiazepine
• Diazepam

References

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