Methylenedioxytrimethylamphetamine
Chemical compound
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Methylenedioxytrimethylamphetamine (MDTA) is a psychoactive drug of the amphetamine class. It is a derivative of methylenedioxyamphetamine (MDA) and is chemically related to methylenedioxymethamphetamine (MDMA), commonly known as ecstasy. MDTA is known for its stimulant and hallucinogenic effects, although it is less well-known and less studied than its more famous relatives.
Chemical structure and properties
MDTA is a member of the substituted amphetamines class, characterized by the presence of a methylenedioxy group attached to the phenyl ring. The chemical structure of MDTA is similar to that of MDMA, with the primary difference being the presence of an additional methyl group on the nitrogen atom. This structural modification influences the drug's pharmacological properties and its interaction with neurotransmitter systems in the brain.
Pharmacology
MDTA acts primarily as a serotonin and dopamine releasing agent. It increases the levels of these neurotransmitters in the synaptic cleft by promoting their release from presynaptic neurons and inhibiting their reuptake. This action is responsible for the drug's mood-enhancing and stimulant effects. The increased serotonin levels can lead to feelings of euphoria, emotional closeness, and altered sensory perception, while the increased dopamine levels contribute to increased energy and alertness.
Effects
The effects of MDTA are similar to those of other entactogens and stimulants. Users may experience:
- Euphoria
- Increased sociability and empathy
- Enhanced sensory perception
- Increased energy and alertness
- Mild hallucinations
The duration of effects typically lasts between 4 to 6 hours, depending on the dose and individual metabolism.
Risks and side effects
As with other psychoactive substances, the use of MDTA carries potential risks and side effects. These may include:
- Increased heart rate and blood pressure
- Anxiety and paranoia
- Insomnia
- Jaw clenching and teeth grinding
- Nausea
Long-term use or high doses can lead to more severe health issues, including neurotoxicity and serotonin syndrome.
Legal status
MDTA is classified as a controlled substance in many countries due to its potential for abuse and lack of medical use. It is illegal to manufacture, possess, or distribute MDTA without a license or prescription.
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Contributors: Prab R. Tumpati, MD