Lipoatrophic diabetes

Lipoatrophic Diabetes

Lipoatrophic diabetes (pronunciation: lip-oh-at-ROH-fik die-uh-BEE-tees) is a rare form of diabetes characterized by the loss of adipose tissue, insulin resistance, and hypertriglyceridemia.

Etymology

The term "lipoatrophic" is derived from the Greek words "lipos" meaning fat, "atrophia" meaning wasting, and "diabetes" from the Greek "diabainein" meaning to pass through, referring to the excessive urination typical of diabetes.

Definition

Lipoatrophic diabetes, also known as lipodystrophic diabetes, is a condition where the body is unable to produce and store fat correctly. This leads to a deficiency of adipose tissue, which is responsible for storing energy in the form of fat, and releasing this energy when the body needs it. The lack of adipose tissue leads to an excess of fat in the blood (hypertriglyceridemia) and liver (hepatic steatosis), and severe insulin resistance.

Symptoms

The symptoms of lipoatrophic diabetes include loss of subcutaneous fat, acanthosis nigricans, hepatomegaly, and hypertriglyceridemia. Patients may also present with insulin resistance, which can lead to hyperglycemia and the development of Type 2 diabetes.

Treatment

Treatment for lipoatrophic diabetes primarily involves managing the symptoms and preventing complications. This may include insulin therapy for managing blood sugar levels, and medications to control high triglyceride levels. In some cases, leptin therapy may be used to replace the hormone leptin, which is normally produced by fat cells.

Related Terms

External links

Medical encyclopedia article on Lipoatrophic diabetes
Wikipedia's article - Lipoatrophic diabetes

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Lipoatrophic diabetes