Linear IgA bullous dermatosis
Linear IgA bullous dermatosis (pronunciation: li-ne-ar I-G-A bu-lous der-ma-to-sis) is a rare autoimmune disease that affects the skin and mucous membranes. The disease is characterized by the linear deposition of IgA antibodies in the dermoepidermal junction.
Etymology
The term "Linear IgA bullous dermatosis" is derived from the characteristic linear deposition of IgA antibodies found in the skin of affected individuals. "Bullous" refers to the formation of blisters or bullae, and "dermatosis" is a general term for any skin disorder.
Symptoms
The primary symptom of Linear IgA bullous dermatosis is the appearance of blisters or bullae on the skin and mucous membranes. These blisters can be filled with fluid and may be painful or itchy. Other symptoms can include fever, malaise, and weight loss.
Causes
Linear IgA bullous dermatosis is an autoimmune disease, which means it is caused by the body's immune system attacking its own tissues. In this case, the immune system produces IgA antibodies that attack the skin and mucous membranes.
Diagnosis
Diagnosis of Linear IgA bullous dermatosis is typically made through a combination of clinical examination, patient history, and laboratory tests. The most definitive test is a skin biopsy, which can reveal the characteristic linear deposition of IgA antibodies.
Treatment
Treatment for Linear IgA bullous dermatosis typically involves medications to suppress the immune system and reduce inflammation, such as corticosteroids and dapsone. In severe cases, hospitalization may be required.
Related Terms
External links
- Medical encyclopedia article on Linear IgA bullous dermatosis
- Wikipedia's article - Linear IgA bullous dermatosis
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