Fluperolone acetate
Fluperolone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is used in the treatment of various inflammatory and autoimmune conditions.
Chemistry
Fluperolone acetate is a synthetic glucocorticoid corticosteroid. It is a derivative of prednisolone, with the hydroxyl group at the 9α position replaced by a fluorine atom and the hydrogen at the 6α position replaced by a methyl group. The acetate ester is attached at the 21 position.
Pharmacology
Fluperolone acetate works by mimicking the effects of cortisol, a hormone naturally produced by the adrenal glands. It binds to and activates the glucocorticoid receptor, leading to changes in gene expression that result in anti-inflammatory and immunosuppressive effects.
Medical uses
Fluperolone acetate is used in the treatment of a variety of inflammatory and autoimmune conditions, including rheumatoid arthritis, lupus, and asthma. It can also be used to treat certain allergic reactions, skin conditions, and eye disorders.
Side effects
Like other corticosteroids, fluperolone acetate can cause a range of side effects. These can include weight gain, mood changes, insomnia, and osteoporosis. Long-term use can also lead to adrenal insufficiency and Cushing's syndrome.
See also
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Fluperolone acetate
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