Fentanyl tropane

Synthetic opioid analgesic

Fentanyl tropane is a synthetic opioid analgesic that is structurally related to both fentanyl and tropane alkaloids. It is a potent compound that has been studied for its potential use in pain management, although it is not commonly used in clinical practice.

Chemical Structure

Chemical structure of Fentanyl tropane

Fentanyl tropane is characterized by the presence of a tropane ring, which is a bicyclic structure that is also found in other compounds such as cocaine and atropine. The addition of the tropane moiety to the fentanyl structure results in a unique pharmacological profile.

Pharmacology

Fentanyl tropane acts primarily as an agonist at the mu-opioid receptor, similar to other opioids. This receptor is responsible for the analgesic effects of opioids, as well as their potential for abuse and dependence. The presence of the tropane ring may influence the binding affinity and selectivity of the compound for opioid receptors.

Mechanism of Action

The mechanism of action of fentanyl tropane involves the activation of the mu-opioid receptor, leading to inhibition of adenylate cyclase activity, decreased intracellular cAMP levels, and reduced neuronal excitability. This results in analgesia, sedation, and euphoria, which are characteristic effects of opioid agonists.

Potential Uses

While fentanyl tropane has been studied for its analgesic properties, its use in clinical settings is limited. The compound's potency and potential for abuse make it a subject of interest primarily in research contexts. It may be used in studies exploring new pain management strategies or the development of novel opioid analgesics with improved safety profiles.

Safety and Toxicity

As with other potent opioids, fentanyl tropane carries a risk of respiratory depression, overdose, and addiction. The presence of the tropane ring may also introduce additional pharmacological effects that could impact its safety profile. Careful consideration of dosing and monitoring is essential when handling this compound in research settings.

Related Compounds

Fentanyl tropane is related to several other compounds, including:

• Fentanyl
• Tropane alkaloids
• Cocaine
• Atropine

Related Pages

• Opioid
• Analgesic
• Mu-opioid receptor
• Synthetic opioid