Crisaborole

What is Crisaborole?

• Crisaborole (EUCRISA) is a phosphodiesterase 4 inhibitor used for the topical treatment of mild to moderate atopic dermatitis in patients 2 years of age and older.

What are the uses of this medicine?

• This medicine is on the skin (topical) to treat mild to moderate eczema (atopic dermatitis) in adults and children 3 months of age and older.

How does this medicine work?

• Crisaborole is a phosphodiesterase 4 (PDE-4) inhibitor.
• PDE-4 inhibition results in increased intracellular cyclic adenosine monophosphate (cAMP) levels.
• The specific mechanism(s) by which crisaborole exerts its therapeutic action for the treatment of atopic dermatitis is not well defined.

Who Should Not Use this medicine ?

This medicine cannot be used in patients with:

• Known hypersensitivity to crisaborole or any component of the formulation.

What drug interactions can this medicine cause?

• No clinically important drug interactions have been observed with EUCRISA.

Is this medicine FDA approved?

• It was approved for use in the United States in 2016.

How should this medicine be used?

Recommended Dosage:

• Apply a thin layer of EUCRISA twice daily to affected areas.

Administration

• Use EUCRISA exactly as your healthcare provider tells you to use it.
• Apply a thin layer of EUCRISA to the affected areas 2 times each day.
• Wash your hands after applying EUCRISA, unless hands are being treated. If someone else applies EUCRISA for you, they should wash their hands after applying EUCRISA.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

• As Ointment, 2%

This medicine is available in fallowing brand namesː

• EUCRISA

What side effects can this medication cause?

The most common side effects of this medicine include:

• application site pain, such as burning or stinging
• Allergic reactions

What special precautions should I follow?

• Hypersensitivity reactions, including contact urticaria, have occurred in patients treated with EUCRISA.
• If signs and symptoms of hypersensitivity occur, discontinue EUCRISA immediately and initiate appropriate therapy.

What to do in case of emergency/overdose?

• In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.

• Overdose related information is also available online at poisonhelp.org/help.
• In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.

Can this medicine be used in pregnancy?

• There is no available data with EUCRISA in pregnant women to inform the drug-associated risk for major birth defects and miscarriage.

Can this medicine be used in children?

• The safety and effectiveness of EUCRISA have been established in pediatric patients ages 3 months and older for topical treatment of mild to moderate atopic dermatitis.
• The safety and effectiveness of EUCRISA in pediatric patients below the age of 3 months have not been established.

What are the active and inactive ingredients in this medicine?

• Active ingredient: crisaborole
• Inactive ingredients: white petrolatum, propylene glycol, mono- and di-glycerides, paraffin, butylated hydroxytoluene, and edetate calcium disodium.

Who manufactures and distributes this medicine?

• Packager: Pfizer Laboratories Div Pfizer Inc

What should I know about storage and disposal of this medication?

• Store at 20°C–25°C (68°F–77°F); excursions permitted to 15°C–30°C (59°F–86°F).
• Keep tube tightly closed.

• Dailymed label info on Crisaborole
• FDA Crisaborole