Etilefrine pivalate

A chemical compound used in medicine

Etilefrine pivalate
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Etilefrine pivalate is a chemical compound that is used in the field of medicine as a prodrug of etilefrine. It is primarily utilized for its vasopressor effects, which help in the management of certain cardiovascular conditions.

Chemical Structure and Properties

Chemical structure of Etilefrine pivalate

Etilefrine pivalate is an ester derivative of etilefrine, where the active drug is modified to improve its pharmacokinetic properties. The pivalate ester is designed to enhance the lipophilicity of the compound, potentially improving its absorption and distribution in the body.

Pharmacology

Etilefrine pivalate acts as a prodrug, meaning it is metabolized in the body to release the active compound, etilefrine. Etilefrine is a sympathomimetic amine that primarily acts on alpha-adrenergic receptors and beta-adrenergic receptors, leading to increased blood pressure and improved cardiac output.

Mechanism of Action

The primary action of etilefrine, once released from its prodrug form, is to stimulate adrenergic receptors. This stimulation results in vasoconstriction and increased heart rate, which are beneficial in conditions where blood pressure support is needed.

Clinical Uses

Etilefrine pivalate is used in the treatment of hypotension, particularly in cases where there is a need for a sustained increase in blood pressure. It may be used in various clinical settings, including during anesthesia or in the management of chronic hypotension.

Administration and Dosage

The dosage of etilefrine pivalate is determined based on the specific needs of the patient and the clinical setting. It is important to monitor the patient's response to the drug to adjust the dosage accordingly.

Side Effects

Common side effects of etilefrine pivalate include tachycardia, palpitations, and headache. As with other sympathomimetic agents, there is a risk of hypertension and arrhythmias, especially at higher doses.

Related Compounds

Etilefrine pivalate is related to other adrenergic agents used in the management of hypotension and other cardiovascular conditions. These include phenylephrine, norepinephrine, and epinephrine.

Related Pages

• Etilefrine
• Sympathomimetic drug
• Vasopressor
• Adrenergic receptor