Lipophilicity
Lipophilicity
Lipophilicity (pronounced: li-po-fi-li-ci-ty) is a chemical property that describes the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents such as hexane or toluene. It is often expressed as the partition coefficient log P between n-octanol and water in the pH environment 7.4.
Etymology
The term "Lipophilicity" is derived from the Greek words "lipos" meaning fat and "philos" meaning loving. It was first used in the early 20th century to describe the affinity of a substance for lipids.
Related Terms
- Hydrophobicity: A physical property of a molecule that is seemingly repelled from a mass of water.
- Partition coefficient: The ratio of concentrations of a compound in a mixture of two immiscible phases at equilibrium.
- Lipophilic efficiency: A measure of the druglikeness of a molecule.
- Bioavailability: The fraction of an administered dose of unchanged drug that reaches the systemic circulation.
- Pharmacokinetics: The study of how an organism affects a drug.
See Also
External links
- Medical encyclopedia article on Lipophilicity
- Wikipedia's article - Lipophilicity
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