Desmethyldiazepam
Desmethyldiazepam (pronunciation: des-meth-yl-diaze-pam), also known as Nordazepam, is a drug which is a Benzodiazepine derivative. It possesses Anxiolytic, Anticonvulsant, Sedative, Hypnotic and Skeletal muscle relaxant properties.
Etymology
The term "Desmethyldiazepam" is derived from its chemical structure. The prefix "des-" indicates the removal of a Methyl group, and "diazepam" refers to the core Benzodiazepine structure of the compound.
Pharmacology
Desmethyldiazepam is a long-acting benzodiazepine drug. It is the primary active metabolite of the benzodiazepine drugs Diazepam and Chlordiazepoxide. It works by enhancing the effect of the neurotransmitter Gamma-aminobutyric acid (GABA) at the GABA_A receptor, resulting in sedative, sleep-inducing, anxiolytic, anticonvulsant, and muscle relaxant properties.
Medical Uses
Desmethyldiazepam is used in the treatment of various conditions including Anxiety disorders, Insomnia, Seizure disorders, and Alcohol withdrawal syndrome. It is also used as a premedication for inducing sedation, anxiolysis, or amnesia before certain medical procedures.
Side Effects
Like other benzodiazepines, Desmethyldiazepam can cause side effects such as drowsiness, fatigue, loss of coordination, and memory impairment. Long-term use can lead to tolerance, dependence, and withdrawal symptoms on discontinuation.
Related Terms
- Benzodiazepine
- Diazepam
- Chlordiazepoxide
- Gamma-aminobutyric acid
- GABA_A receptor
- Anxiety disorders
- Insomnia
- Seizure disorders
- Alcohol withdrawal syndrome
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