Daprodustat
Daprodustat (pronounced da-pro-doo-stat) is a pharmaceutical drug used in the treatment of anemia associated with chronic kidney disease (CKD). It is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) that stimulates the production of red blood cells in the body.
Etymology
The name "Daprodustat" is derived from the chemical structure of the drug. The prefix "Dapro-" is a contraction of the chemical name "3,4-dihydroxy-2-propanone", while "-dustat" is a common suffix used in the names of drugs that inhibit a specific enzyme or process.
Pharmacology
Daprodustat works by inhibiting the enzyme prolyl hydroxylase, which is involved in the degradation of hypoxia-inducible factors (HIFs). By inhibiting this enzyme, Daprodustat allows HIFs to accumulate in the body, leading to increased production of erythropoietin, a hormone that stimulates the production of red blood cells.
Clinical Use
Daprodustat is used in the treatment of anemia associated with chronic kidney disease. It is particularly useful in patients who are not responsive to or cannot tolerate other treatments for anemia, such as erythropoiesis-stimulating agents (ESAs).
Related Terms
- Anemia: A condition characterized by a deficiency of red blood cells or of hemoglobin in the blood.
- Chronic Kidney Disease (CKD): A long-term condition where the kidneys do not work effectively.
- Erythropoietin: A hormone produced by the kidneys that promotes the formation of red blood cells in the bone marrow.
- Hypoxia-Inducible Factors (HIFs): Proteins that respond to decreases in available oxygen in the cellular environment, or hypoxia.
External links
- Medical encyclopedia article on Daprodustat
- Wikipedia's article - Daprodustat
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