Collagen-induced arthritis

Collagen-induced arthritis (pronunciation: /ˈkɒlədʒɪn ɪnˈdjuːst ɑːrˈθraɪtɪs/) is a form of rheumatoid arthritis that is induced in laboratory animals for research purposes. It is a widely used model for studying the pathogenesis of rheumatoid arthritis and testing potential therapeutic agents.

Etymology

The term "collagen-induced arthritis" is derived from the method of inducing the disease, which involves injecting the animal with an emulsion of collagen (a protein found in connective tissues) and an adjuvant. The immune system of the animal reacts to the collagen, leading to inflammation and arthritis.

Pathogenesis

In collagen-induced arthritis, the immune system mistakenly attacks the body's own tissues, leading to inflammation and damage. This is similar to what happens in rheumatoid arthritis in humans. The disease is induced by injecting the animal with an emulsion of collagen and an adjuvant, which triggers an immune response. The immune cells attack the collagen in the joints, leading to inflammation and arthritis.

Related Terms

Rheumatoid arthritis: A chronic inflammatory disorder affecting many joints, including those in the hands and feet.
Collagen: The most abundant protein in the body, found in the skin, bones, muscles, and tendons.
Adjuvant: A substance that enhances the body's immune response to an antigen.
Antigen: A substance that induces an immune response in the body, especially the production of antibodies.
Inflammation: A localized physical condition in which part of the body becomes reddened, swollen, hot, and often painful, especially as a reaction to injury or infection.