Butamisole

Chemical compound

Butamisole
[[File: Chemical structure of Butamisole |frameless|220px|alt=|]]
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number	14860-53-8
PubChem	3047765
DrugBank
ChemSpider	2310100
KEGG	D03068

Butamisole is a chemical compound that belongs to the class of imidazolidinones. It is primarily known for its use as an anthelmintic agent, which means it is used to treat infections caused by parasitic worms.

Chemical Properties

Butamisole is characterized by its chemical structure, which includes a butyl group attached to a phenyl ring, and an imidazolidinone moiety. The presence of these functional groups contributes to its biological activity.

Mechanism of Action

As an anthelmintic, Butamisole works by interfering with the energy metabolism of the parasitic worms. It inhibits the enzyme fumarate reductase, which is crucial for the anaerobic energy metabolism of the parasites. This disruption leads to the depletion of energy reserves in the worms, ultimately causing their death.

Uses

Butamisole is used in veterinary medicine to treat infections caused by various types of parasitic worms in animals. It is effective against a range of nematodes, which are a type of roundworm. The drug is administered orally and is absorbed into the bloodstream, where it exerts its effects on the parasites.

Safety and Side Effects

While Butamisole is effective in treating parasitic infections, it is important to use it under the guidance of a veterinarian. Overdosage or improper use can lead to adverse effects in animals, including gastrointestinal disturbances and neurological symptoms.

Related Compounds

Butamisole is related to other imidazolidinone compounds that also possess anthelmintic properties. These compounds share a similar mechanism of action and are used in the treatment of parasitic infections.

Related Pages

• Anthelmintic
• Imidazolidinone
• Parasitic worm
• Fumarate reductase