Basophil cell

Basophil cell is a type of white blood cell that plays a crucial role in the immune system. Basophils are the least common of the granulocytes, constituting about 0.01% to 0.3% of circulating white blood cells. Despite their rarity, they are important players in immune response, particularly in response to parasitic infections and in allergic reactions.

Function

Basophils contain large cytoplasmic granules which store and release histamine and heparin. Histamine is a chemical that contributes to inflammatory response, while heparin is an anticoagulant. When an allergen enters the body, it triggers the basophils to release these chemicals, leading to inflammation and other symptoms of an allergic reaction.

Development

Basophils are produced in the bone marrow from stem cells. They mature in the bone marrow before being released into the bloodstream. The lifespan of a basophil in the circulation is typically 1-2 days.

Role in Disease

Basophils play a role in several diseases. In allergic reactions, they are responsible for the release of histamine and other chemicals that cause symptoms. They are also involved in autoimmune diseases, where they can contribute to inflammation and tissue damage. In addition, elevated basophil counts can be a sign of certain types of leukemia or other blood disorders.

See Also

• Eosinophil
• Neutrophil
• White blood cell
• Immune system
• Allergy

Basophil cell gallery

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  Histology of pars distalis of the anterior pituitary with chromophobes, basophils, and acidophils, annotated