Appendix cancer

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC

Appendix cancer
Appendiceal carcinoid
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Abdominal pain, bloating, changes in bowel habits
Complications	Peritoneal carcinomatosis, bowel obstruction
Onset	Typically in adulthood
Duration	Variable
Types	Carcinoid tumor, mucinous adenocarcinoma, goblet cell carcinoid
Causes	Unknown
Risks	Family history, smoking, obesity
Diagnosis	CT scan, MRI, biopsy
Differential diagnosis	Appendicitis, ovarian cancer, colorectal cancer
Prevention	N/A
Treatment	Surgery, chemotherapy, radiation therapy
Medication	N/A
Prognosis	Depends on stage and type
Frequency	Rare
Deaths	N/A

Appendix neoplasms by incidence and prognosis

Histopathology of appendiceal carcinoid

Histopathology of low-grade appendiceal mucinous neoplasm

Appendix cancer is a rare type of cancer that occurs in the appendix, a small, tube-shaped pouch attached to the large intestine. This type of cancer can be challenging to diagnose due to its rarity and the non-specific nature of its symptoms.

Types

Appendix cancer can be classified into several types based on the type of cells involved:

• Carcinoid tumors: These are the most common type of appendix cancer and originate from the hormone-producing cells of the appendix. They are often slow-growing and may not cause symptoms until they are advanced.
• Adenocarcinoma: This type of cancer arises from the glandular cells lining the appendix. It is more aggressive than carcinoid tumors and can spread to other parts of the body.
• Mucinous adenocarcinoma: This subtype is characterized by the production of mucin, a jelly-like substance. It can lead to a condition known as pseudomyxoma peritonei, where mucin accumulates in the abdominal cavity.
• Signet ring cell carcinoma: A rare and aggressive form of adenocarcinoma, signet ring cell carcinoma is named for the appearance of the cancer cells under a microscope.
• Goblet cell carcinoid: This is a hybrid tumor with features of both adenocarcinoma and carcinoid tumors. It tends to be more aggressive than typical carcinoid tumors.

Symptoms

Symptoms of appendix cancer can be vague and may include:

• Abdominal pain or discomfort
• Bloating or a feeling of fullness
• Changes in bowel habits
• Unexplained weight loss
• Nausea and vomiting

In some cases, appendix cancer is discovered incidentally during surgery for another condition, such as appendicitis.

Diagnosis

Diagnosis of appendix cancer typically involves a combination of:

• Imaging studies: Such as CT scans or MRIs to visualize the appendix and surrounding tissues.
• Biopsy: A sample of tissue may be taken to confirm the diagnosis and determine the type of cancer.
• Blood tests: To check for tumor markers and assess overall health.

Treatment

Treatment options for appendix cancer depend on the type and stage of the cancer and may include:

• Surgery: The primary treatment for localized appendix cancer is surgical removal of the appendix, often along with part of the colon and surrounding tissues.
• Chemotherapy: Used to kill cancer cells or shrink tumors, especially in cases where the cancer has spread.
• Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC): A specialized treatment for pseudomyxoma peritonei, involving the surgical removal of tumors followed by the direct application of heated chemotherapy to the abdominal cavity.

Prognosis

The prognosis for appendix cancer varies widely depending on the type and stage of the cancer. Carcinoid tumors generally have a better prognosis than adenocarcinomas. Early detection and treatment are crucial for improving outcomes.

See also

• Appendicitis
• Gastrointestinal cancer
• Neuroendocrine tumor