Ankylosing vertebral hyperostosis with tylosis

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Ankylosing vertebral hyperostosis with tylosis
Autosomal dominant - en.svg
Synonyms Forestier's disease with tylosis
Pronounce N/A
Specialty Rheumatology
Symptoms Back pain, stiffness, thickened skin on palms and soles
Complications N/A
Onset Middle age
Duration Chronic
Types N/A
Causes Genetic mutation
Risks Family history
Diagnosis X-ray, CT scan, MRI
Differential diagnosis Ankylosing spondylitis, Diffuse idiopathic skeletal hyperostosis
Prevention N/A
Treatment Physical therapy, pain management, surgery
Medication NSAIDs, analgesics
Prognosis Variable, depends on severity
Frequency Rare
Deaths N/A


Alternate names

Familial ankylosing vertebral hyperostosis with tylosis

Definition

A rare dysostosis with predominant vertebral involvement characterized by paraspinal ligament ossification (most pronounced in the lower thoracic region), osteophytosis, marginal sacroiliac joint sclerosis, and punctate hyperkeratosis on the soles and palms. Patients may be asymptomatic or present mild to moderate back pain. There have been no further descriptions in the literature since 1969.

NIH genetic and rare disease info

Ankylosing vertebral hyperostosis with tylosis is a rare disease.

Rare and genetic diseases

Rare diseases - Ankylosing vertebral hyperostosis with tylosis

A-Z list of rare diseases
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Contributors: Deepika vegiraju, Prab R. Tumpati, MD