Altanserin
Altanserin is a compound used in scientific research to study the serotonin receptor system in the brain. It acts as a highly selective 5-HT2A receptor antagonist.
Chemistry
Altanserin is a derivative of the chemical class of phenylpiperazines. It is structurally related to the neurotransmitter serotonin, but has been modified to allow it to bind more selectively to certain serotonin receptor subtypes.
Pharmacology
Altanserin acts as an antagonist at the 5-HT2A receptor subtype. This means that it binds to these receptors and prevents them from being activated by serotonin or other agonists. This property makes Altanserin a useful tool in research, as it allows scientists to selectively block the 5-HT2A receptors and study their function in the brain.
Uses in Research
Altanserin has been used in a variety of research contexts. It is often used in animal studies to investigate the role of the 5-HT2A receptors in behavior. For example, it has been used to study the role of these receptors in the effects of hallucinogenic drugs, as these drugs are thought to exert their effects primarily through the 5-HT2A receptors.
Altanserin is also used in human research. It can be labeled with a radioactive isotope and used in Positron Emission Tomography (PET) scans to visualize the distribution of 5-HT2A receptors in the brain. This can be useful in studying a variety of psychiatric disorders, including schizophrenia, depression, and anxiety disorders.
Safety and Side Effects
As a research tool, Altanserin is not intended for human consumption outside of a controlled research setting. Therefore, its safety profile and potential side effects are not well-studied. However, as a 5-HT2A receptor antagonist, it could theoretically have side effects similar to other drugs in this class, which can include sedation, weight gain, and cognitive impairment.
See Also
| Serotonin receptor modulators | ||||||
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Contributors: Prab R. Tumpati, MD
